Shao Minmin, Xiong Guofeng, Xiang Guangzao, Xu Shile, Zhang Liqun
Department of Otorhinolaryngology, The Second Affiliated Hospital of Shanghai University (Wenzhou Central Hospital), Wenzhou, China.
Ann Transl Med. 2021 Apr;9(8):676. doi: 10.21037/atm-21-907.
To investigate the correlation between blood lipids and the prognosis of idiopathic sudden sensorineural hearing loss (ISSNHL).
We included 232 patients with ISSNHL at the Second Affiliated Hospital of Shanghai University from June 2015 to March 2017 using a prospective cohort study design. We collected information including age, gender, hypertension, diabetes, mellitus, vertigo, as well as the levels of blood total cholesterol (TC), triglycerides (TG), and low-density lipoproteins (LDL-C). We also recorded the ratio between the levels of low-density lipoproteins and the levels of high-density lipoproteins (LDL-C/HDL-C ratio). Correlations between the prognosis of ISSNHL and TC, TG, LDL-C, and LDL-C/HDL-C ratio were analyzed by univariable and multivariable logistic regression analyses.
The clinical effectiveness rate of patients with TC ranging from 5.2 to 6.2 mmol/L was significantly higher than that of patients with TC <5.2 mmol/L (P<0.001). No notable difference was found between patients with TC <5.2 mmol/L and patients with TC ≥6.2 mmol/L. The clinical effectiveness rate of patients in TG ranging from 1.7 mmol/L to 2.3 mmol/L was markedly higher than those in TG <1.7 mmol/L (P<0.001). No significant difference was found between patients with TG ranging from 2.3 to 5.6 mmol/L, TG ≥5.6 mmol/L, and TG <1.7 mmol/L. The clinical effectiveness rate of patients in LDL-C/HDL-C <1.5 was considerably higher than those in LDL-C/HDL-C ranging from 1.5 to 2.5, 2.5 to 3.5, and ≥3.5 (P<0.001).
Our findings indicated that TC, TG, and the LDL-C/HDL-C ratio are strongly associated with the prognosis of ISSNHL. These three indices could be recommended as independent markers to predict outcomes.
探讨血脂与特发性突发性感音神经性听力损失（ISSNHL）预后的相关性。
采用前瞻性队列研究设计，纳入2015年6月至2017年3月在上海大学附属第二医院就诊的232例ISSNHL患者。收集患者的年龄、性别、高血压、糖尿病、眩晕情况，以及血总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL-C）水平，并记录低密度脂蛋白与高密度脂蛋白水平之比（LDL-C/HDL-C比值）。通过单因素和多因素逻辑回归分析，分析ISSNHL预后与TC、TG、LDL-C及LDL-C/HDL-C比值之间的相关性。
TC在5.2至6.2 mmol/L之间的患者临床有效率显著高于TC<5.2 mmol/L的患者（P<0.001）。TC<5.2 mmol/L的患者与TC≥6.2 mmol/L的患者之间未发现显著差异。TG在1.7至2.3 mmol/L之间的患者临床有效率明显高于TG<1.7 mmol/L的患者（P<0.001）。TG在2.3至5.6 mmol/L之间、TG≥5.6 mmol/L的患者与TG<1.7 mmol/L的患者之间未发现显著差异。LDL-C/HDL-C<1.5的患者临床有效率显著高于LDL-C/HDL-C在1.5至2.5、2.5至3.5及≥3.5之间的患者（P<0.001）。
我们的研究结果表明，TC、TG及LDL-C/HDL-C比值与ISSNHL的预后密切相关。这三个指标可作为预测预后的独立标志物。
