Dai Qingqing, Wang Dan, Zheng Hong
Department of Otolaryngology, Sichuan University, West China Hospital, Chengdu, Sichuan, China.
J Int Adv Otol. 2019 Apr;15(1):130-134. doi: 10.5152/iao.2019.5076.
To investigate the correlation between KCNE gene family and Meniere's disease (MD) in the Chinese population.
This study analyzed the single-nucleotide polymorphism (SNP) of KCNE1 and KCNE3 genes between the MD group and the control group and between the familial Meniere's disease (FMD) group and the sporadic Meniere's disease (SMD) group.
A total of 653 C/T SNPs of KCNE1 had a statistical difference between the FMD and SMD groups (p=0.0082<0.05); 492 A/C SNPs of KCNE3 were statistically different between the FMD group and the control group (genotype p=0.037<0.05 and allele p=0.006<0.05).
SNPs of KCNE1 and KCNE3 gene mutations were, respectively, different between the SMD and FMD groups. KCNE3 gene polymorphism was key to FMD disease, whereas KCNE1 was more important to the onset of SMD.
研究中国人群中KCNE基因家族与梅尼埃病（MD）之间的相关性。
本研究分析了MD组与对照组之间以及家族性梅尼埃病（FMD）组与散发性梅尼埃病（SMD）组之间KCNE1和KCNE3基因的单核苷酸多态性（SNP）。
KCNE1的653个C/T SNP在FMD组和SMD组之间存在统计学差异（p = 0.0082<0.05）；KCNE3的492个A/C SNP在FMD组与对照组之间存在统计学差异（基因型p = 0.037<0.05，等位基因p = 0.006<0.05）。
KCNE1和KCNE3基因的SNP在SMD组和FMD组之间分别存在差异。KCNE3基因多态性是FMD疾病的关键，而KCNE1对SMD的发病更为重要。
