Department of Pulmonology, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Department of Pediatrics, Shaoxing People's Hospital, Shaoxing, Zhejiang, China.
J Chin Med Assoc. 2019 May;82(5):343-350. doi: 10.1097/JCMA.0000000000000094.
Asthma is a chronic inflammatory disease of the airways in which many cells are involved, including mast cells, eosinophils, T lymphocytes, and so on. During the process, many chemokines and mediators are released to engage in recruiting and activating eosinophils and other inflammatory cells. Also, some signaling pathways are involved in the pathobiology of asthma. Sonic hedgehog (Shh) is one of the members of hedgehog gene families. Shh signaling plays a critical role in the embryonic development, including the lung. Previous findings from our team reveal that Shh is involved in the asthma pathogenesis. Recombinant Shh could induce the CC chemokine ligand 2 (CCL2) overexpressing and Smo inhibitor GDC-O449 could inhibit CCL2 expression in airway epithelial cells, monocytes, or macrophages. Hence, we reviewed the effects of Shh and CCL2 signaling pathways, and the interaction between signaling pathways in asthma.
哮喘是一种气道的慢性炎症性疾病，其中涉及许多细胞，包括肥大细胞、嗜酸性粒细胞、T 淋巴细胞等。在这个过程中，许多趋化因子和介质被释放出来，以招募和激活嗜酸性粒细胞和其他炎症细胞。此外，一些信号通路也参与了哮喘的病理生理学。Sonic hedgehog（Shh）是 hedgehog 基因家族的成员之一。Shh 信号在胚胎发育中起着关键作用，包括肺部。我们团队的先前研究发现，Shh 参与了哮喘的发病机制。重组 Shh 可以诱导 CC 趋化因子配体 2（CCL2）的过度表达，而 Smo 抑制剂 GDC-O449 可以抑制气道上皮细胞、单核细胞或巨噬细胞中 CCL2 的表达。因此，我们综述了 Shh 和 CCL2 信号通路的作用，以及信号通路在哮喘中的相互作用。
