Saleh Velez Faddi G, Pinto Camila B, Bailin Emma S, Münger Marionna, Ellison Andrew, Costa Beatriz T, Crandell David, Bolognini Nadia, Merabet Lotfi B, Fregni Felipe
Laboratory of Neuromodulation & Center for Clinical Research Learning, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital; University of Chicago Medical Center, Department of Neurology, University of Chicago.
Laboratory of Neuromodulation & Center for Clinical Research Learning, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital; Department of Neuroscience and Behavior, Psychology Institute, University of Sao Paulo.
J Vis Exp. 2019 Apr 20(146). doi: 10.3791/58800.
Mirror therapy (MT) has been proposed as an effective rehabilitative strategy to alleviate pain symptoms in amputees with phantom limb pain (PLP). However, establishing the neural correlates associated with MT therapy have been challenging given that it is difficult to administer the therapy effectively within a magnetic resonance imaging (MRI) scanner environment. To characterize the functional organization of cortical regions associated with this rehabilitative strategy, we have developed a combined behavioral and functional neuroimaging protocol that can be applied in participants with a leg amputation. This novel approach allows participants to undergo MT within the MRI scanner environment by viewing real-time video images captured by a camera. The images are viewed by the participant through a system of mirrors and a monitor that the participant views while lying on the scanner bed. In this manner, functional changes in cortical areas of interest (e.g., sensorimotor cortex) can be characterized in response to the direct application of MT.
镜像疗法（MT）已被提出作为一种有效的康复策略，用于减轻患有幻肢痛（PLP）的截肢者的疼痛症状。然而，鉴于在磁共振成像（MRI）扫描仪环境中难以有效实施该疗法，确定与MT疗法相关的神经关联一直具有挑战性。为了表征与这种康复策略相关的皮质区域的功能组织，我们开发了一种结合行为和功能神经成像的方案，该方案可应用于腿部截肢的参与者。这种新颖的方法允许参与者通过观看由相机捕获的实时视频图像在MRI扫描仪环境中接受MT。参与者通过镜子系统和躺在扫描仪床上时观看的监视器来观看图像。通过这种方式，可以表征感兴趣的皮质区域（例如，感觉运动皮层）对MT直接应用的功能变化。
