McLaurin Kristen A, Moran Landhing M, Li Hailong, Booze Rosemarie M, Mactutus Charles F
Program in Behavioral Neuroscience, Department of Psychology, University of South Carolina.
Program in Behavioral Neuroscience, Department of Psychology, University of South Carolina;
J Vis Exp. 2019 Apr 19(146). doi: 10.3791/58659.
Temporal processing deficits have been implicated as a potential elemental dimension of higher-level cognitive processes, commonly observed in neurocognitive disorders. Despite the popularization of prepulse inhibition (PPI) in recent years, many current protocols promote using a percent of control measure, thereby precluding the assessment of temporal processing. The present study used cross-modal PPI and gap prepulse inhibition (gap-PPI) to demonstrate the benefits of employing a range of interstimulus intervals (ISIs) to delineate effects of sensory modality, psychostimulant exposure, and age. Assessment of sensory modality, psychostimulant exposure, and age reveals the utility of an approach varying the interstimulus interval (ISI) to establish the shape of the ISI function, including increases (sharper curve inflections) or decreases (flattening of the response amplitude curve) in startle amplitude. Additionally, shifts in peak response inhibition, suggestive of a differential sensitivity to the manipulation of ISI, are often revealed. Thus, the systematic manipulation of ISI affords a critical opportunity to evaluate temporal processing, which may reveal the underlying neural mechanisms involved in neurocognitive disorders.
时间处理缺陷被认为是高级认知过程的一个潜在基本维度，在神经认知障碍中普遍存在。尽管近年来预脉冲抑制（PPI）已得到普及，但目前许多方案都提倡使用对照测量的百分比，从而排除了对时间处理的评估。本研究使用跨模态PPI和间隔预脉冲抑制（间隙-PPI）来证明采用一系列刺激间隔（ISI）来描绘感觉模态、精神兴奋剂暴露和年龄的影响的益处。对感觉模态、精神兴奋剂暴露和年龄的评估揭示了一种改变刺激间隔（ISI）的方法的实用性，以建立ISI函数的形状，包括惊吓幅度的增加（更尖锐的曲线拐点）或减少（反应幅度曲线变平）。此外，通常会揭示峰值反应抑制的变化，这表明对ISI操纵的敏感性不同。因此，对ISI的系统操纵提供了一个评估时间处理的关键机会，这可能揭示神经认知障碍中涉及的潜在神经机制。
