Moran Landhing M, Hord Lauren L, Booze Rosemarie M, Harrod Steven B, Mactutus Charles F
Department of Psychology, Program in Behavioral Neuroscience, University of South Carolina, Columbia, SC, 29208.
Dev Psychobiol. 2016 Mar;58(2):211-22. doi: 10.1002/dev.21366. Epub 2015 Sep 29.
Deficits in prepulse inhibition (PPI), a measure of sensorimotor gating, are observed in neurodevelopmental and neuropsychiatric disorders. Despite the large PPI literature, the majority of studies characteristically employ tests with one interstimulus interval (ISI), of one modality, at one age. In the context of the auditory startle response (ASR), the present study examined (1) the profile for the ontogeny of PPI through adulthood in Long-Evans hooded rats with a reasonably comprehensive ISI function, (2) whether the ontogenetic profile for PPI is sensitive to modality of the prepulse stimulus, as a within-session variable, and (3) whether the maturation of PPI differs for males and females. Despite the basic effect of more pronounced PPI in adult relative to preweanling animals, each sensory modality displayed a unique ontogenetic profile for PPI, without any compelling evidence for major differences between males and females, in accordance with the known temporal course of peripheral and central maturational profiles of sensory systems in the rat. The context for assessing auditory PPI (auditory and tactile vs. auditory and visual prepulses) influenced the overall startle response, i.e., a shift in the height of the entire profile, but did not significantly impact the auditory PPI profile per se. The translational relevance of preclinical sensorimotor assessments to patients with neurodevelopmental and/or neuropsychiatric disorders depends partly on an understanding of the ontogeny of sensorimotor gating in different sensory systems, and can be strengthened with the use of a reasonably comprehensive number of ISIs to provide relatively precise and defined response functions.
前脉冲抑制（PPI）是一种感觉运动门控的测量指标，在神经发育障碍和神经精神疾病中会出现缺陷。尽管有大量关于PPI的文献，但大多数研究的特点是在一个年龄阶段，采用一种刺激间隔（ISI）、一种模态的测试。在听觉惊吓反应（ASR）的背景下，本研究考察了：（1）通过成年期，具有合理全面ISI功能的Long-Evans Hooded大鼠PPI个体发育情况；（2）作为会话内变量，PPI的个体发育情况是否对前脉冲刺激的模态敏感；（3）PPI的成熟在雄性和雌性之间是否存在差异。尽管成年动物相对于断奶前动物的PPI更明显是基本效应，但每种感觉模态都显示出独特的PPI个体发育情况，没有任何令人信服的证据表明雄性和雌性之间存在重大差异，这与大鼠感觉系统外周和中枢成熟情况的已知时间进程一致。评估听觉PPI的背景（听觉和触觉与听觉和视觉前脉冲）影响了整体惊吓反应，即整个曲线高度的变化，但本身并未显著影响听觉PPI曲线。临床前感觉运动评估与神经发育和/或神经精神疾病患者的转化相关性部分取决于对不同感觉系统中感觉运动门控个体发育的理解，并且可以通过使用合理数量的ISI来提供相对精确和明确的反应函数来加强。
