Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Immunology Research Center, Inflammation and Inflammatory Diseases Division, Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Autoimmun Rev. 2019 Jul;18(7):738-748. doi: 10.1016/j.autrev.2019.05.012. Epub 2019 May 4.
CD4 T helper (Th) cells are a crucial player in host defense but under certain conditions can contribute to the pathogenesis of inflammatory and autoimmune diseases. Beside the Th1/Th2 subset, several additional Th subsets have been identified, each with a distinctive transcription factor, functional properties, signature cytokine profile, and possible role in the pathophysiology of diseases. These newer Th subsets include Th17, regulatory Th cells (Tregs), and more recently, Th9, Th22, and follicular T helper cells. Interestingly, imbalance of Th subsets contributes to the immunopathology of several disease states. Therefore, targeting the imbalance of Th subsets and their signature cytokine profiles by a safe, effective and inexpensive nutraceutical agent such as curcumin could be helpful to treat autoimmune and inflammatory diseases. In this study different Th subsets and how the imbalance of these subsets could promote pathology of several diseases has been reviewed. Furthermore, the role of curcumin in this process will be discussed and the impact of targeting Th subsets by curcumin.
CD4+ T 辅助（Th）细胞是宿主防御的关键参与者，但在某些条件下，它们也可能导致炎症和自身免疫性疾病的发病机制。除了 Th1/Th2 亚群外，还已经确定了几种其他的 Th 亚群，每个亚群都具有独特的转录因子、功能特性、特征细胞因子谱以及在疾病病理生理学中的可能作用。这些更新的 Th 亚群包括 Th17、调节性 T 细胞（Tregs），以及最近的 Th9、Th22 和滤泡性 T 辅助细胞。有趣的是，Th 亚群的失衡导致了几种疾病状态的免疫病理学。因此，通过一种安全、有效且廉价的营养药物（如姜黄素）来靶向 Th 亚群及其特征细胞因子谱的失衡，可能有助于治疗自身免疫性和炎症性疾病。在这项研究中，我们回顾了不同的 Th 亚群以及这些亚群的失衡如何促进几种疾病的发病机制。此外，我们还将讨论姜黄素在这一过程中的作用以及姜黄素对 Th 亚群的靶向作用的影响。
