a Regional Department for Eating Disorders, Division of Mental Health and Addiction , Oslo University Hospital , Oslo , Norway.
b Department of Heart and Vascular Care , Christiana Care Health System , Newark , DE , USA.
J Clin Exp Neuropsychol. 2019 Aug;41(6):653-663. doi: 10.1080/13803395.2019.1610160. Epub 2019 May 7.
: Anorexia nervosa (AN) is associated with deficits in set-shifting and cognitive flexibility, yet less is known about the persistence of these deficits after recovery and how they might contribute to reported difficulties organizing and learning new information. To address this question, the current study applied a process-focused approach, that accounts for errors and strategies by which a score is achieved, to investigate the relationship between verbal memory and executive function in women remitted from AN. : Twenty-six women remitted from anorexia nervosa (RAN) and 25 control women (CW) aged 19-45 completed the California Verbal Learning Test, Second edition (CVLT-II) and the Wisconsin Card Sorting Test (WCST). Groups were compared on overall achievement scores, and on repetition, intrusion, and perseverative errors on both tests. Associations between learning and memory performance and WCST errors were also examined. : RAN and CW groups did not differ on overall CVLT-II learning and memory performance or errors on the WCST, though the RAN group trended towards greater WCST non-perseverative and total errors. On the CVLT-II, the RAN group made significantly more repetition errors than CW (p = 0.010), and within-trial perseveration (WTP) errors (p = 0.044). For the CW group, CVLT-II learning and memory performance were negatively associated with errors on the WCST, whereas among RAN, primarily delayed memory was negatively correlated with WCST errors. Notably, for RAN, greater WCST perseverative responses were correlated with greater CVLT-II repetition and WTP errors, showing the convergence of perseverative responding across tasks. : Despite similar overall learning and memory performance, difficulties with executive control seem to persist even after symptom remission in patients with AN. Results indicate an inefficient learning process in the cognitive phenotype of AN and support the use of process approaches to refine neuropsychological assessment of AN by accounting for strategy use.
神经性厌食症(AN)与定势转移和认知灵活性缺陷有关,但对于这些缺陷在恢复后的持续性以及它们如何导致报告的组织和学习新信息的困难知之甚少。为了解决这个问题,本研究采用了一种注重过程的方法,该方法考虑了达到分数的错误和策略,以调查从 AN 中恢复过来的女性的言语记忆和执行功能之间的关系。
26 名从神经性厌食症(RAN)中恢复的女性和 25 名年龄在 19-45 岁的对照组女性完成了加利福尼亚言语学习测验第二版(CVLT-II)和威斯康星卡片分类测验(WCST)。比较了两组的总体成绩,以及两组在两项测试中的重复、侵入和持续错误。还检查了学习和记忆表现与 WCST 错误之间的关联。
RAN 和 CW 组在 CVLT-II 的整体学习和记忆表现或 WCST 错误上没有差异,尽管 RAN 组在 WCST 上的非持续和总错误上呈趋势。在 CVLT-II 上,RAN 组比 CW 组的重复错误明显更多(p = 0.010),内试持续错误(WTP)更多(p = 0.044)。对于 CW 组,CVLT-II 的学习和记忆表现与 WCST 上的错误呈负相关,而在 RAN 组中,主要是延迟记忆与 WCST 错误呈负相关。值得注意的是,对于 RAN 组,WCST 中更多的持续反应与 CVLT-II 中更多的重复和 WTP 错误相关,表明在任务中持续反应的收敛。
尽管总体学习和记忆表现相似,但在 AN 患者症状缓解后,执行控制方面的困难似乎仍然存在。结果表明,AN 的认知表型存在低效的学习过程,并支持使用过程方法来通过考虑策略的使用来完善对 AN 的神经心理学评估。