Krediet R T, Zuyderhoudt F M, Boeschoten E W, Arisz L
Eur J Clin Invest. 1987 Feb;17(1):43-52. doi: 10.1111/j.1365-2362.1987.tb01224.x.
The in situ intraperitoneal volume and the mass transfer area coefficients (MTC) of urea, lactate, creatinine, glucose, kanamycin, inulin, beta 2-microglobulin, albumin and IgG were studied in eight continuous ambulatory peritoneal dialysis (CAPD) patients. All patients were studied during a 4-h dialysis dwell, first during peritonitis and subsequently after recovery from the infection. The maximal intraperitoneal volume was reached at 68 min during peritonitis and at 150 min in the study after recovery (P less than 0.01), suggesting increased water transport during the infection. For all investigated solutes MTCs were higher in the presence of peritonitis than after recovery. This increase was most marked for the proteins (greater than 100%). The power curve relationships between MTCs and molecular weight indicated that peritoneal transport of the low- and middle-molecular weight solutes was determined by free diffusion and that the infection-induced rise was due to an increase in effective surface area. For protein transport restricted diffusion was found. The increase of this transport during peritonitis was probably caused by both a larger effective surface area and a higher vascular permeability.
对8例持续性非卧床腹膜透析（CAPD）患者的腹膜内原位容积以及尿素、乳酸、肌酐、葡萄糖、卡那霉素、菊粉、β2-微球蛋白、白蛋白和免疫球蛋白的传质面积系数（MTC）进行了研究。所有患者均在4小时透析驻留期间进行研究，先是在腹膜炎期间，随后是在感染恢复后。腹膜炎期间在68分钟时达到最大腹膜内容积，感染恢复后的研究中在150分钟时达到最大腹膜内容积（P<0.01），提示感染期间水转运增加。对于所有研究的溶质，腹膜炎时的MTC高于恢复后。这种增加在蛋白质方面最为明显（大于100%）。MTC与分子量之间的幂曲线关系表明，低分子量和中分子量溶质的腹膜转运由自由扩散决定，感染引起的升高是由于有效表面积增加。对于蛋白质转运，发现存在限制扩散。腹膜炎期间这种转运的增加可能是由更大的有效表面积和更高的血管通透性共同导致的。
