Studio Italiano di Oftalmologia, Via Livenza 3, 00198 Rome, Italy.
Vision Engineering Italy srl, Via Livenza 3, 00198 Rome, Italy; Consiglio Nazionale delle Ricerche, Istituto per i Processi Chimico-Fisici, V.le Stagno D'Alcontres 37, 98158 Messina, Italy.
Cont Lens Anterior Eye. 2019 Dec;42(6):662-665. doi: 10.1016/j.clae.2019.04.019. Epub 2019 May 4.
To investigate the corneal epithelial thickness profiles in patients with a confirmed diagnosis of stable and progressive keratoconus.
Studio Italiano di Oftalmologia, Rome, Italy.
Observational study.
86 patients with either stable (n = 52) or progressive (n = 34) keratoconus and 182 healthy controls were enrolled in the study. Disease progression was confirmed by repeated corneal topographies over 1 year follow-up before inclusion in the study. All subjects had full corneal and epithelial thickness mapping taken by spectral domain optical coherence tomography (SD-OCT). The full corneal mapping was investigated by evaluating the central corneal thickness, the thinnest point, the superonasal-inferotemporal thickness difference and the minimum-median thickness difference. The epithelial mapping was investigated by assessing the 2 mm central thickness, the inferior paracentral (2-5 mm) thickness, and the minimum-maximum thickness difference.
No significant differences in full corneal mapping were found between stable and progressive keratoconic eyes. Of note, the inferior paracentral region of the corneal epithelium was significantly thinner in progressive (50 ± 3 μm) than stable (53 ± 4 μm) keratoconus (P < 0.001).
The SD-OCT corneal epithelial mapping was valuable for detecting local thickness changes in eyes with keratoconus. Monitoring the corneal epithelial changes across the inferior area in patients with keratoconus could be worthy for assessing disease progression.
研究已确诊的稳定型和进展型圆锥角膜患者的角膜上皮厚度分布。
意大利罗马的 Studio Italiano di Oftalmologia。
观察性研究。
本研究纳入了 86 例稳定型（n=52）或进展型（n=34）圆锥角膜患者和 182 例健康对照者。在纳入研究之前，通过对角膜地形图进行 1 年以上的重复检查，确认了疾病的进展。所有患者均接受了光谱域光学相干断层扫描（SD-OCT）的全角膜和上皮厚度测绘。通过评估中央角膜厚度、最薄点、超鼻下-颞下厚度差异和最小-中位数厚度差异，对全角膜测绘进行了研究。通过评估 2mm 中央厚度、下旁中心（2-5mm）厚度和最小-最大厚度差异，对上皮测绘进行了研究。
稳定型和进展型圆锥角膜眼之间的全角膜测绘无显著差异。值得注意的是，进展型圆锥角膜的角膜上皮下旁中心区域（50±3μm）明显比稳定型圆锥角膜（53±4μm）薄（P<0.001）。
SD-OCT 角膜上皮测绘有助于检测圆锥角膜眼中的局部厚度变化。监测圆锥角膜患者下区的角膜上皮变化可能有助于评估疾病进展。
