使用傅里叶域光学相干断层扫描进行角膜上皮厚度测绘以检测forme fruste圆锥角膜。
Corneal epithelial thickness mapping using Fourier-domain optical coherence tomography for detection of form fruste keratoconus.
作者信息
Temstet Cyril, Sandali Otman, Bouheraoua Nacim, Hamiche Taous, Galan Alice, El Sanharawi Mohamed, Basli Elena, Laroche Laurent, Borderie Vincent
机构信息
From Centre Hospitalier National d'Ophtalmologie des XV-XX (Temstet, Sandali, Bouheraoua, Hamiche, Galan, El Sanharawi, Basli, Laroche, Borderie), Pierre et Marie Curie University, and Research Team 968 (Bouheraoua, Laroche, Borderie), Institut de la Vision, Paris, France.
From Centre Hospitalier National d'Ophtalmologie des XV-XX (Temstet, Sandali, Bouheraoua, Hamiche, Galan, El Sanharawi, Basli, Laroche, Borderie), Pierre et Marie Curie University, and Research Team 968 (Bouheraoua, Laroche, Borderie), Institut de la Vision, Paris, France.
出版信息
J Cataract Refract Surg. 2015 Apr;41(4):812-20. doi: 10.1016/j.jcrs.2014.06.043.
PURPOSE
To determine whether optical coherence tomography (OCT) epithelial mapping can improve the detection of form fruste keratoconus.
SETTING
French National Eye Hospital, Paris 6 Pierre & Marie Curie University, Paris, France.
DESIGN
Retrospective comparative study.
METHODS
Eyes with normal corneas, form fruste keratoconus, moderate keratoconus, or severe keratoconus were assessed using Fourier-domain OCT (RTVue 5.5), scanning-slit corneal topography (Orbscan IIz), and rotating Scheimpflug camera (Pentacam Comprehensive Eye Scanner). Several parameters provided by the software or derived from elevation maps, OCT pachymetric maps, and OCT epithelium parameters were evaluated and compared between the 4 groups.
RESULTS
The study involved 145 eyes. There were no significant differences in the keratometry (K) value, inferior-superior value, keratoconus index, central K index, and topographic keratoconus classification indices between the form fruste keratoconus group and the control group (P > .05). Form fruste keratoconic corneas had less epithelial thickness in the thinnest corneal zone than normal corneas, and greater epithelial thickness in the thinnest corneal zone than keratoconic corneas (P < .005). The epithelial thickness in the thinnest corneal zone in form fruste corneas was located inferiorly (P < .005) and corresponded with the zone of minimum epithelial thickness and maximum posterior elevation (P < .005). The receiver operating characteristic curve analysis showed good overall predictive accuracy of the epithelial thickness in the thinnest corneal zone, with a 52 μm threshold value for discriminating form fruste keratoconic corneas from normal corneas.
CONCLUSIONS
The epithelial thickness in the thinnest corneal zone and its location provided by the OCT epithelial mapping might be useful for the early diagnosis of form fruste keratoconus.
FINANCIAL DISCLOSURE
No author has a financial or proprietary interest in any material or method mentioned.
目的
确定光学相干断层扫描（OCT）上皮层测绘能否改善forme fruste圆锥角膜的检测。
设置
法国巴黎皮埃尔与玛丽·居里大学附属法国国家眼科医院。
设计
回顾性比较研究。
方法
使用傅里叶域OCT（RTVue 5.5）、扫描裂隙角膜地形图（Orbscan IIz）和旋转Scheimpflug相机（Pentacam综合眼部扫描仪）对正常角膜、forme fruste圆锥角膜、中度圆锥角膜或重度圆锥角膜的眼睛进行评估。对软件提供的或从高度图、OCT测厚图和OCT上皮参数得出的几个参数进行评估，并在4组之间进行比较。
结果
该研究纳入了145只眼睛。forme fruste圆锥角膜组与对照组之间在角膜曲率（K）值、上下值、圆锥角膜指数、中央K指数和地形学圆锥角膜分类指数方面无显著差异（P > 0.05）。forme fruste圆锥角膜的角膜最薄区上皮厚度比正常角膜薄，比圆锥角膜厚（P < 0.005）。forme fruste角膜最薄角膜区的上皮厚度位于下方（P < 0.005），且与上皮最薄和后表面高度最大的区域相对应（P < 0.005）。受试者操作特征曲线分析显示，角膜最薄区上皮厚度具有良好的总体预测准确性，区分forme fruste圆锥角膜和正常角膜的阈值为52μm。
结论
OCT上皮层测绘提供的角膜最薄区上皮厚度及其位置可能有助于forme fruste圆锥角膜的早期诊断。
财务披露
没有作者对文中提及的任何材料或方法拥有财务或专利权益。
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