Bamberger U, Scheuber P H, Sailer-Kramer B, Hammer D K
Int Arch Allergy Appl Immunol. 1987;82(3-4):272-4. doi: 10.1159/000234204.
The immediate-type skin reaction in unsensitized monkeys upon challenge with staphylococcal enterotoxin B (SEB) was studied to define the role of mast cell receptors in the action of the toxin. For this purpose anti-idiotypic antibodies (anti-Id) were raised in BALB/c mice against monoclonal anti-SEB antibodies and purified by idiotype affinity chromatography. Anti-Id completely abolished skin reactions upon challenge with SEB without having biological functions itself. The data are compatible with the view that receptors for staphylococcal enterotoxin actually exist on the mast cell membrane of primates and anti-Id may be of potential value to influence the course of staphylococcal enterotoxin-mediated effects.
研究了未致敏猴子在受到金黄色葡萄球菌肠毒素B（SEB）攻击时的速发型皮肤反应，以确定肥大细胞受体在毒素作用中的作用。为此，在BALB/c小鼠中产生针对单克隆抗SEB抗体的抗独特型抗体（抗Id），并通过独特型亲和层析进行纯化。抗Id在受到SEB攻击时完全消除了皮肤反应，而其本身没有生物学功能。这些数据与以下观点相符，即灵长类动物肥大细胞膜上实际存在金黄色葡萄球菌肠毒素的受体，抗Id可能对影响金黄色葡萄球菌肠毒素介导的效应过程具有潜在价值。
