Tokunaga A, Onda M, Shimizu Y, Yoshiyuki T, Nishi K, Matsukura N, Tanaka N, Moriyama Y, Yamashita K, Yoshiba M
Jpn J Cancer Res. 1987 Mar;78(3):242-50.
Non-simultaneous primary malignant tumors in five different organs were detected in a case of cancer family syndrome, and the patient's offspring were found to have colorectal cancers during follow-up. The first cancer in the patient was found in the transverse colon at the age of 47, and partial colectomy was carried out. The second and third were cancers of the cecum and gallbladder which were found concurrently at the age of 61, and ileocecal resection and cholecystectomy were carried out simultaneously. The fourth was cancer of the urinary bladder which was found at the age of 66, and partial cystectomy with interstitial irradiation using a radon seed in the residual urinary bladder was carried out. The fifth was cancer of the stomach at the age of 72, and subtotal gastrectomy was carried out. All of the resected specimens were demonstrated to be different carcinomas histologically. The father and 5 of the 7 siblings of this patient suffered from gastrointestinal or uterine cancers. Furthermore, two daughters of this patient were affected with cancer; the younger with cancer of the descending colon at the age of 47, and the elder with cancers of the transverse colon and rectum at the age of 54. Thus, familial clustering of cancer was shown. Genetic characteristics may have contributed to the development of multiple primary cancers in this family.
在一例癌症家族综合征患者中，检测到五个不同器官出现非同时性原发性恶性肿瘤，且在随访期间发现患者的后代患有结直肠癌。该患者的首例癌症于47岁时在横结肠被发现，并进行了部分结肠切除术。第二例和第三例分别是盲肠癌和胆囊癌，于61岁时同时被发现，随即同时进行了回盲部切除术和胆囊切除术。第四例是膀胱癌，于66岁时被发现，并对残余膀胱进行了镭种子间质照射的部分膀胱切除术。第五例是胃癌，于72岁时被发现，并进行了胃次全切除术。所有切除标本经组织学检查均显示为不同的癌。该患者的父亲及7个兄弟姐妹中的5人患有胃肠道或子宫癌。此外，该患者的两个女儿也患了癌症；小女儿在47岁时患降结肠癌，大女儿在54岁时患横结肠癌和直肠癌。因此，显示出癌症的家族聚集性。遗传特征可能促使了这个家族中多发原发性癌症的发生。
