神经性厌食症的胃肠道改变 - 系统综述。
Gastrointestinal alterations in anorexia nervosa - A systematic review.
机构信息
Charité Center for Internal Medicine and Dermatology, Department for Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Department of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, Tübingen, Germany.
出版信息
Eur Eat Disord Rev. 2019 Sep;27(5):447-461. doi: 10.1002/erv.2679. Epub 2019 May 7.
OBJECTIVE
Anorexia nervosa (AN) is an eating disorder characterized by body schema disruptions, underweight (>15% reduction of the ideal body weight or a body mass index <17.5 kg/m ), self-induced weight reduction, and endocrine impairments. The three latter features greatly impact on most physiological functions including the cardiovascular, skeletal, reproductive, and the gastrointestinal system, which results in an increased mortality rate in affected individuals. Especially, gastrointestinal alterations are described as particularly bothersome by patients.
METHODS
To address the need for a better understanding of the interplay between AN and the gastrointestinal (GI) tract, a systematic data search in the databases Medline, Embase, and PsycINFO was conducted.
RESULTS
Over 1,235 studies were identified, out of these, 107 appropriate articles were selected and discussed in the present review.
CONCLUSION
AN has large impact on GI alterations and symptoms; conversely, GI symptoms may also affect the manifestation and course of AN as discussed in the present review. Despite increasing data, several gaps in knowledge exist especially on the pathophysiology underlying the changes described.
目的
神经性厌食症（AN）是一种以身体意象障碍、体重过轻（理想体重的 15%以下或 BMI<17.5kg/m²）、自我诱导的体重减轻和内分泌紊乱为特征的进食障碍。后三个特征极大地影响了大多数生理功能，包括心血管、骨骼、生殖和胃肠道系统，导致受影响个体的死亡率增加。特别是，胃肠道改变被患者描述为特别麻烦。
方法
为了更好地理解 AN 与胃肠道（GI）之间的相互作用，我们在 Medline、Embase 和 PsycINFO 数据库中进行了系统的数据搜索。
结果
共确定了超过 1235 项研究，其中 107 项合适的文章在本综述中进行了讨论。
结论
AN 对胃肠道改变和症状有很大影响；相反，胃肠道症状也可能影响 AN 的表现和病程，正如本综述中所讨论的那样。尽管数据不断增加，但仍存在一些知识空白，特别是在描述的变化的病理生理学方面。
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