甲泛葡胺对全血氧亲和力的影响。
Effect of metrizamide on whole blood oxygen affinity.
作者信息
Berglund S, Almén T, Johansson B W
出版信息
Acta Radiol Diagn (Stockh). 1978;19(4):688-92. doi: 10.1177/028418517801900414.
The effects on whole blood oxygen affinity following addition to human blood of either ionic (diatrizoate) or non-ionic (metrizamide) contrast medium were investigated in vitro. No medium changed whole blood oxygen affinity. Solutions of metrizamide produced less changes in plasma pH than solutions of diatrizoate. This difference is explained by lower buffer capacity and lower osmolality of metrizamide solutions. Low osmolality gives less redistribution of anions between plasma and red cells and therefore less decrease in plasma pH.
在体外研究了向人血中添加离子型（泛影酸盐）或非离子型（甲泛葡胺）造影剂后对全血氧亲和力的影响。两种造影剂均未改变全血氧亲和力。甲泛葡胺溶液引起的血浆pH值变化小于泛影酸盐溶液。这种差异可通过甲泛葡胺溶液较低的缓冲能力和较低的渗透压来解释。低渗透压使阴离子在血浆和红细胞之间的重新分布较少，因此血浆pH值降低也较少。
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