Araco Antonino
Cosmetic Surgeon at Villa Salaria, private hospital , Rome , Italy.
J Cosmet Laser Ther. 2019;21(6):309-315. doi: 10.1080/14764172.2019.1605448. Epub 2019 May 7.
: The goal of our prospective study was to assess the efficacy of the topical Platelet-rich plasma on reducing superficial perioral wrinkles and restoring the dermal matrix. : 50 women with moderate to severe perioral wrinkles were treated on the perioral area by a single session of fractional CO2 laser skin resurfacing plus intradermal injection of prp. 25 patients (group 1) applied topically prp twice a day for 12 weeks as post laser treatment. 25 (group 2) applied gentamicin and betamethasone twice a day for the first 7 days and then hyaluronic acid gel for the following 12 weeks. : In group 1, moisture ( < 0.001), amount of collagen fiber ( < 0.001) skin elasticity ( < 0.001), PSAl ( < 0.001) and SSAl ( < 0.001) improved significantly. In group 2 all the parameters investigated improved but did not reach significant difference. : Our medical device with a plasma-like formulation is able to maintain prp active for a period of 7 days so patients are able to apply topically growth factors at home. : Our prospective study proves that the use of topical prp reduces superficial perioral wrinkles and restore dermal matrix when used at home for 12 weeks.
我们前瞻性研究的目的是评估局部应用富血小板血浆在减少口周浅表皱纹和恢复真皮基质方面的疗效。50名患有中度至重度口周皱纹的女性在口周区域接受了单次分次二氧化碳激光皮肤磨削术加皮内注射prp治疗。25名患者（第1组）在激光治疗后每天局部应用prp两次，持续12周。25名患者（第2组）在最初7天每天应用庆大霉素和倍他米松两次，然后在接下来的12周应用透明质酸凝胶。在第1组中，水分（<0.001）、胶原纤维量（<0.001）、皮肤弹性（<0.001）、PSAl（<0.001）和SSAl（<0.001）均有显著改善。在第2组中，所有研究参数均有改善，但未达到显著差异。我们具有血浆样配方的医疗器械能够使prp在7天内保持活性，因此患者能够在家中局部应用生长因子。我们的前瞻性研究证明，在家中使用12周时，局部应用prp可减少口周浅表皱纹并恢复真皮基质。
