The Kennedy Institute of Rheumatology, University of Oxford, Oxford, U.K.
Biochem Soc Trans. 2019 Jun 28;47(3):811-826. doi: 10.1042/BST20180363. Epub 2019 May 7.
Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a type I transmembrane proteinase that belongs to the matrix metalloproteinase (MMP) family. It is a potent modifier of cellular microenvironment and promotes cell migration and invasion of a wide variety of cell types both in physiological and pathological conditions. It promotes cell migration by degrading extracellular matrix on the cell surface and creates a migration path, by modifying cell adhesion property by shedding cell adhesion molecules to increase cell motility, and by altering cellular metabolism. Thus, MT1-MMP is a multifunctional cell motility enhancer. In this review, we will discuss the current understanding of the proteolytic and non-proteolytic mechanism of MT1-MMP-dependent cell migration.
膜型 1 基质金属蛋白酶（MT1-MMP）是一种 I 型跨膜蛋白酶，属于基质金属蛋白酶（MMP）家族。它是细胞微环境的有效调节剂，在生理和病理条件下促进多种细胞类型的细胞迁移和侵袭。它通过降解细胞表面的细胞外基质来促进细胞迁移，并通过脱落细胞黏附分子来改变细胞黏附特性从而增加细胞迁移能力，从而创建迁移路径，通过改变细胞代谢来改变细胞运动性。因此，MT1-MMP 是一种多功能的细胞运动增强因子。在这篇综述中，我们将讨论当前对 MT1-MMP 依赖性细胞迁移的蛋白水解和非蛋白水解机制的理解。
