Lundqvist Johan, Helmersson Erik, Oskarsson Agneta
Department of Biomedicine and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Dose Response. 2019 Apr 28;17(2):1559325819843374. doi: 10.1177/1559325819843374. eCollection 2019 Apr-Jun.
Sodium meta-arsenite (NaAsO) has been suggested to play a role both in initiation/progression of prostate cancer and as a future antiprostate cancer drug. We have studied the effects of NaAsO on cell proliferation of prostate cancer and noncancer cells, breast cancer cells, and adrenocortical carcinoma cells in vitro. Further, we have investigated the effect of NaAsO on the androgen receptor. We report that NaAsO alters the cell proliferation of prostate cells, in a hormetic manner, by increasing cell proliferation at low concentrations and decreasing the cell proliferation at high concentrations. No activation of the androgen receptor was detected. We conclude that NaAsO is able to increase cell proliferation of prostate cells in vitro at low concentrations, while it decreases cell viability at high concentrations. This novel finding has to be further addressed if NaAsO should be developed into an antiprostate cancer drug.
亚砷酸钠（NaAsO）被认为在前列腺癌的起始/进展过程中发挥作用，并且有望成为一种抗前列腺癌药物。我们在体外研究了亚砷酸钠对前列腺癌细胞、非癌细胞、乳腺癌细胞和肾上腺皮质癌细胞增殖的影响。此外，我们还研究了亚砷酸钠对雄激素受体的作用。我们报告称，亚砷酸钠以一种 hormetic 方式改变前列腺细胞的增殖，在低浓度时增加细胞增殖，在高浓度时降低细胞增殖。未检测到雄激素受体的激活。我们得出结论，亚砷酸钠在体外低浓度时能够增加前列腺细胞的增殖，而在高浓度时会降低细胞活力。如果要将亚砷酸钠开发成一种抗前列腺癌药物，这一新发现还需要进一步研究。
