Kumar Kishore, Tariq Hassan, Ahmed Rafeeq, Chukwunonso Chime, Niazi Masooma, Ihimoyan Ariyo
Department of Medicine, Bronxcare Health System, Bronx, New York, USA.
Division of Gastroenterology, Bronxcare Health System, Bronx, New York, USA.
Case Rep Oncol Med. 2019 Apr 1;2019:8968034. doi: 10.1155/2019/8968034. eCollection 2019.
The poorly differentiated small-cell type, neuroendocrine carcinoma (NEC) of the gallbladder is a very uncommon subtype of a neuroendocrine tumor of the gastrointestinal tract. Nonsecretory NEC by virtue of its nonspecific and subtle clinical presentation of the tumor is usually diagnosed at an advance stage with presenting symptoms related to either locally advance disease or from metastatic disease. Though the radiologic imaging does identify the gall bladder cancer, the tumor lacks a specific diagnostic test; therefore, the diagnosis is almost always confirmed on histopathologic and immunohistochemical staining. We present a case of a poorly differentiated, small-cell neuroendocrine tumor of the gallbladder. The patient died within 3 months after the definitive diagnosis was made. Survival from this deadly malignancy can be improved with aggressive surgical treatment followed by chemotherapy and radiotherapy on a case-by-case scenario. The systemic chemotherapy remained the treatment of choice for an unresectable tumor (Chen et al., 2014).
胆囊低分化小细胞型神经内分泌癌（NEC）是胃肠道神经内分泌肿瘤中一种非常罕见的亚型。非分泌性NEC由于其肿瘤临床表现不特异且隐匿，通常在疾病晚期出现与局部进展或转移相关的症状时才得以诊断。尽管影像学检查能够识别胆囊癌，但该肿瘤缺乏特异性诊断检测方法；因此，诊断几乎总是通过组织病理学和免疫组化染色来确诊。我们报告一例胆囊低分化小细胞神经内分泌肿瘤病例。患者在确诊后3个月内死亡。对于这种致命性恶性肿瘤，通过积极的手术治疗，随后根据具体情况进行化疗和放疗，其生存率可能会得到提高。全身化疗仍然是不可切除肿瘤的首选治疗方法（Chen等，2014年）。
