Zheng Tingting, Peng Jiao, Pei Tao, Shi Yu, Liu Li, Chen Keke, Xiao Haitao, Chen Yun
1Department of Ultrasound, Peking University Shenzhen Hospital, Shenzhen, 518036 Guangdong China.
Shenzhen Key Laboratory for Drug Addiction and Medication Safety, Biomedical Research Institute, Biomedical Research Institute, Shenzhen PKU-HKUST Medical Center, Shenzhen, 518036 Guangdong China.
3 Biotech. 2019 May;9(5):195. doi: 10.1007/s13205-019-1697-5. Epub 2019 May 2.
Traumatic brain injury leads to problems with movement and cognitive deficits and has a high mortality rate. Cornel iridoid glycoside, the active ingredient of , has been reported to ameliorate apoptosis and inflammation in rats. We investigated the therapeutic effect of cornel iridoid glycoside on neuroinflammation in rats with brain injury. Rats were treated with cornel iridoid glycoside, and then measurements of antioxidant, proinflammatory marker, and NF-κB and STAT3 mRNA and protein levels, as well as a histopathologic analysis, were conducted. Cornel iridoid glycoside significantly reduced lipid peroxidation and TNF-α and IL-6 levels but increased the levels of antioxidants. In addition, cornel iridoid glycoside significantly decreased the expression of NF-κB and STAT3. Histopathological analyses showed that cornel iridoid glycoside reduced the severity of neuroinflammation and apoptosis. Therefore, cornel iridoid glycoside significantly ameliorated neuroinflammation by reducing lipid peroxidation and proinflammatory marker levels and increasing antioxidant levels in rats with brain injury.
创伤性脑损伤会导致运动问题和认知缺陷，且死亡率很高。山茱萸环烯醚萜苷是[具体药物名称未给出]的活性成分，据报道其可改善大鼠的细胞凋亡和炎症。我们研究了山茱萸环烯醚萜苷对脑损伤大鼠神经炎症的治疗作用。给大鼠使用山茱萸环烯醚萜苷进行治疗，然后测定抗氧化剂、促炎标志物以及NF-κB和STAT3的mRNA和蛋白水平，并进行组织病理学分析。山茱萸环烯醚萜苷显著降低了脂质过氧化以及TNF-α和IL-6水平，但提高了抗氧化剂水平。此外，山茱萸环烯醚萜苷显著降低了NF-κB和STAT3的表达。组织病理学分析表明，山茱萸环烯醚萜苷减轻了神经炎症和细胞凋亡的严重程度。因此，山茱萸环烯醚萜苷通过降低脂质过氧化和促炎标志物水平以及提高脑损伤大鼠的抗氧化剂水平，显著改善了神经炎症。
