Lemonnier F, Delhotal-Landes B, Couturier M, Decimo D, Odiévre M, Gautier M, Lemonnier A
J Inherit Metab Dis. 1987;10(1):52-61. doi: 10.1007/BF01799488.
The utilization of fructose and glucose by fibroblast cultures obtained from patients with hereditary fructose intolerance (HFI) was studied in comparison with fibroblast controls. The cell growth, the time course of D-glucose or D-fructose uptake and the consumption of fructose were similar for both HFI and control cells. Some results showed significant differences between these two cell types: HFI cells consumed less glucose, produced less lactate and contained less glycogen than control cells. Furthermore, significantly less [U-14C]D-glucose and [U-14C]D-fructose was incorporated into lipids in HFI cells than in control cells. The mechanisms responsible for these differences observed between the two cell types are not known.
对从患有遗传性果糖不耐受症（HFI）的患者身上获取的成纤维细胞培养物中果糖和葡萄糖的利用情况进行了研究，并与成纤维细胞对照进行了比较。HFI细胞和成纤维细胞对照在细胞生长、D - 葡萄糖或D - 果糖摄取的时间进程以及果糖消耗方面相似。一些结果显示这两种细胞类型之间存在显著差异：HFI细胞消耗的葡萄糖较少，产生的乳酸较少，并且所含糖原比对照细胞少。此外，与对照细胞相比，HFI细胞中掺入脂质的[U - 14C]D - 葡萄糖和[U - 14C]D - 果糖明显更少。导致这两种细胞类型之间观察到这些差异的机制尚不清楚。
