Zhou Fanfan, Li Ruoyu, Wang Xiao, Du Simin, An Zesheng
Institute of Nanochemistry and Nanobiology, College of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
Qianweichang College, Shanghai University, Shanghai, 200444, China.
Angew Chem Int Ed Engl. 2019 Jul 8;58(28):9479-9484. doi: 10.1002/anie.201904413. Epub 2019 Jun 5.
Inspired by DNA photolyase, a non-natural photoenzymatic catalysis of common flavoproteins is developed for controlled radical polymerization under irradiation of visible light. This photoenzymatic polymerization is highly efficient under mild conditions, applicable to various monomer families, suitable for both homogeneous and heterogeneous media, and can be externally modulated by switching light on and off. A unique combination of the natural enzymatic deoxygenation with the non-natural photoenzymatic process enables an unprecedented oxygen-tolerant, visible-light-controlled radical polymerization using a single enzyme to be developed. Visible light activation of non-natural catalytic functions of the widely distributed flavoproteins is an exciting conceptual advance and may uncover a hitherto underexplored field of photoenzymatic catalysis.
受DNA光解酶的启发，人们开发了一种常见黄素蛋白的非天然光酶催化反应，用于在可见光照射下进行可控自由基聚合。这种光酶聚合在温和条件下效率很高，适用于各种单体家族，适用于均相和非均相介质，并且可以通过开关光进行外部调节。天然酶促脱氧与非天然光酶过程的独特结合，使得开发一种前所未有的、使用单一酶的耐氧可见光控制自由基聚合成为可能。广泛分布的黄素蛋白的非天然催化功能的可见光激活是一个令人兴奋的概念性进展，可能会揭示一个迄今为止尚未充分探索的光酶催化领域。
