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诊断为非甲非乙型肝炎的急慢性肝病患者血清中缺乏乙肝病毒DNA序列。

Lack of hepatitis B virus DNA sequences in sera from patients with acute and chronic liver diseases diagnosed as non-A, non-B-hepatitis.

作者信息

Slusarczyk J, Hess G, Hansson B G, Meyer Zum Büschenfelde K H

出版信息

Liver. 1986 Dec;6(6):337-40. doi: 10.1111/j.1600-0676.1986.tb00301.x.

DOI:10.1111/j.1600-0676.1986.tb00301.x
PMID:3106742
Abstract

The sera of 15 individuals with transfusion-associated acute or chronic non A, non B hepatitis, which lacked hepatitis B virus markers, were tested for hepatitis B virus DNA by dot blot hybridization test. Three sera of two patients positive in this test, however, also gave positive results when the labeled plasmid was used as probe instead of labeled HBV-DNA, indicating false positive results in the initial test. In conclusion, the data indicated that sera of patients with confirmed non A, non B hepatitis do not contain DNA-sequences in the serum hybridizing with HBV-DNA.

摘要

对15例输血相关的急性或慢性非甲非乙型肝炎患者(其血清缺乏乙肝病毒标志物)的血清进行斑点杂交试验,以检测乙肝病毒DNA。然而,在该试验中呈阳性的两名患者的三份血清,当使用标记质粒而非标记乙肝病毒DNA作为探针时,也得出了阳性结果,这表明初始试验结果为假阳性。总之,数据表明,确诊为非甲非乙型肝炎患者的血清中不含有能与乙肝病毒DNA杂交的血清DNA序列。

相似文献

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Lack of hepatitis B virus DNA sequences in sera from patients with acute and chronic liver diseases diagnosed as non-A, non-B-hepatitis.诊断为非甲非乙型肝炎的急慢性肝病患者血清中缺乏乙肝病毒DNA序列。
Liver. 1986 Dec;6(6):337-40. doi: 10.1111/j.1600-0676.1986.tb00301.x.
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Hepatitis B virus DNA in serum from patients with acute hepatitis B.
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[The relation of B- and non-A, non-B hepatitis virus--hepatitis B virus (HBV) DNA hybridization studies of the sera in non-A, non-B hepatitis].
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引用本文的文献

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Geographical variation in prevalence of hepatitis B virus DNA in HBsAg negative patients.乙肝表面抗原阴性患者中乙肝病毒DNA流行率的地理差异。
J Clin Pathol. 1993 Apr;46(4):304-8. doi: 10.1136/jcp.46.4.304.
2
In vitro amplification of hepatitis B virus sequences from liver tumour DNA and from paraffin wax embedded tissues using the polymerase chain reaction.利用聚合酶链反应从肝肿瘤DNA及石蜡包埋组织中进行乙肝病毒序列的体外扩增。
J Clin Pathol. 1989 Aug;42(8):840-6. doi: 10.1136/jcp.42.8.840.