Zheng Qianwen, Li Yawen, Zhang Lu, Yao Qiang, Zhang Jing, Li Mier, Wang Ju, Zhu Cairong
Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2019 Apr 30;39(4):422-427. doi: 10.12122/j.issn.1673-4254.2019.04.07.
To investigate the association between alcohol drinking and all-cause death in patients with ischemic stroke.
Between January, 2010 and July, 2018, consecutive patients with first-episode ischemic stroke admitted in the West China Hospital, Sichuan University were enrolled, and all the patients were followed up every 3 months.Chi-square test was used to compare the differences in the baseline characteristics between the pre-stroke drinkers and the nondrinkers.The Cox regression model was used to analyze the effects of drinking status, drinking years, drinking frequency, average single alcohol intake before stroke and drinking status during the follow-up period on the mortality of patients after discharge.
A total of 855 patients with ischemic stroke were enrolled, and deaths occurred in 140 of these patients.Chi-square test showed significant differences in gender ( < 0.001), weekly physical exercise time (=0.035), smoking ( < 0.001), and heart disease ( < 0.001) between the pre-stroke drinkers and nondrinkers.Multivariate Cox regression analysis showed that drinking during the follow-up period (=0.001), drinking for less than 28 years before stroke (=0.035) and a moderate drinking frequency (5 to 20 times per month for males and 4 to 9 times per month for females; =0.030) were associated with a lowered risk of death after discharge.No significant effects of pre-stroke drinking status or average single alcohol intake were found on death after ischemic stroke.
The drinking years and drinking frequency before stroke and drinking status during the follow-up period are related to the all-cause mortality in patients with ischemic stroke.Investigations of the more specific variables of drinking behaviors during the follow-up period are needed to further clarify the association between drinking and death after ischemic stroke.
探讨饮酒与缺血性脑卒中患者全因死亡之间的关联。
选取2010年1月至2018年7月在四川大学华西医院收治的连续首发缺血性脑卒中患者，所有患者每3个月进行一次随访。采用卡方检验比较卒中前饮酒者和不饮酒者基线特征的差异。采用Cox回归模型分析饮酒状态、饮酒年限、饮酒频率、卒中前平均单次饮酒量及随访期间饮酒状态对出院后患者死亡率的影响。
共纳入855例缺血性脑卒中患者，其中140例死亡。卡方检验显示，卒中前饮酒者和不饮酒者在性别（<0.001）、每周体育锻炼时间（=0.035）、吸烟（<0.001）和心脏病（<0.001）方面存在显著差异。多因素Cox回归分析显示，随访期间饮酒（=0.001）、卒中前饮酒少于28年（=0.035）和适度饮酒频率（男性每月5至20次，女性每月4至9次；=0.030）与出院后死亡风险降低相关。未发现卒中前饮酒状态或平均单次饮酒量对缺血性脑卒中后死亡有显著影响。
卒中前饮酒年限、饮酒频率及随访期间饮酒状态与缺血性脑卒中患者的全因死亡率有关。需要对随访期间饮酒行为的更具体变量进行研究，以进一步阐明饮酒与缺血性脑卒中后死亡之间的关联。
