Masi M, Paolucci P, Timoncini G, Fantini M P, Chiodo F, Franceschi C
Boll Ist Sieroter Milan. 1978 Sep 30;57(4):464-70.
T and B peripheral blood lymphocytes were studied in five children affected by chronic persistent hepatitis HBsAg-positive. The percentage of E rosette forming cells was found decreased while thymidine uptake after Phytohaemagglutinin stimulation reached values higher than that of normal controls. Null cells were found increased. In all the patients the percentage of IgG bearing lymphocytes was markedly decreased. Such alterations of T cells compartement are similar to those found by other authors in the aggressive form. The hypothesis of a derangement of T cell subpopulation regulatory activity is put forward.
对5名慢性持续性乙肝表面抗原阳性患儿的外周血T淋巴细胞和B淋巴细胞进行了研究。发现E玫瑰花结形成细胞的百分比降低，而植物血凝素刺激后的胸腺嘧啶核苷摄取量高于正常对照组。发现裸细胞增加。所有患者中携带IgG的淋巴细胞百分比均显著降低。T细胞区室的这种改变与其他作者在侵袭性形式中发现的改变相似。提出了T细胞亚群调节活性紊乱的假说。
