Levo Y, Shouval D, Tur-Kaspa R, Wollner S, Penchas S, Zlotnick A, Eliakim M
Clin Exp Immunol. 1981 Apr;44(1):63-7.
The immune system of 69 asymptomatic HBsAg carriers with normal liver function tests was evaluated. B cell function, as documented by serum immunoglobulin levels, number of mouse rosette-forming lymphocytes and lymphocyte reactivity to staphylococcal protein A, was intact. On the other hand, T cell function was markedly impaired. This was manifested by a significant decrease in E rosette-forming lymphocytes, an increase in stable rosette-forming cells and decreased reactivity to phytohaemagglutinin and concanavalin A. These data rule out the possibility that the immunological aberrations associated with hepatitis B infection are secondary to liver injury. The abnormal immune state either precedes the viral infection, thus predisposing to the acquisition of a carrier state or, alternatively, is a direct result of the infection.
对69例肝功能检查正常的无症状乙肝表面抗原携带者的免疫系统进行了评估。血清免疫球蛋白水平、小鼠玫瑰花结形成淋巴细胞数量以及淋巴细胞对葡萄球菌蛋白A的反应性所记录的B细胞功能是完整的。另一方面，T细胞功能明显受损。这表现为E玫瑰花结形成淋巴细胞显著减少、稳定玫瑰花结形成细胞增加以及对植物血凝素和刀豆球蛋白A的反应性降低。这些数据排除了与乙型肝炎感染相关的免疫异常继发于肝损伤的可能性。异常免疫状态要么先于病毒感染，从而易导致携带者状态的获得，要么是感染的直接结果。
