Shikowitz M J, Steinberg B M, Winkler B, Abramson A L
Otolaryngol Head Neck Surg. 1986 Jul;95(1):31-6. doi: 10.1177/019459988609500108.
Squamous metaplasia following tracheotomy has been well documented. Most studies have dealt primarily with changes at--or adjacent to--the cuff site and have failed to evaluate its effect in the distal trachea. We have used rabbits as experimental models for the induction of tracheal squamous metaplasia, using uncuffed tracheotomy tubes. Rabbits were routinely killed 24, 36, 48, 72, 120, and 168 hours posttracheotomy, and the entire larynx, trachea, and main-stem bronchi were step-sectioned for histologic examination. Patchy areas of squamous metaplasia were found in all rabbits with tracheotomy equal to or longer than 48 hours. The metaplasia appeared to increase with time of intubation. Induction of squamous metaplasia (following tracheotomy as a contributing factor to the spread of laryngeal papillomatosis) is discussed.
气管切开术后的鳞状化生已有充分的文献记载。大多数研究主要关注套管部位或其附近的变化，而未能评估其在气管远端的影响。我们使用无套管的气管切开导管，将兔子作为诱导气管鳞状化生的实验模型。兔子在气管切开术后24、36、48、72、120和168小时常规处死，将整个喉、气管和主支气管进行连续切片以进行组织学检查。在所有气管切开时间等于或超过48小时的兔子中均发现了散在的鳞状化生区域。化生似乎随着插管时间的延长而增加。文中讨论了鳞状化生的诱导（气管切开术后作为喉乳头状瘤病传播的一个促成因素）。
