未经放疗的气管支气管幼年型乳头状瘤病的恶性转化

Malignant transformation of tracheobronchial juvenile papillomatosis without prior radiotherapy.

作者信息

Siegel S E, Cohen S R, Isaacs H, Stanley P

出版信息

Ann Otol Rhinol Laryngol. 1979 Mar-Apr;88(2 Pt 1):192-7. doi: 10.1177/000348947908800208.

Abstract

Squamous cell carcinoma of the trachea and bronchi developed in a 19-year-old male with recurrent laryngeal papillomata since age four, who had received no prior radiotherapy, but who was tracheotomized for obstructive laryngeal papillomata. Treatment with intravenous cytosine arabinoside, "moderate dose" methotrexate, topical 5-fluorouracil and irradiation failed to alter tumor growth, and the patient succumbed to recurrent arterial tumor emboli.

摘要

一名19岁男性患有气管和支气管鳞状细胞癌，该患者自4岁起就患有复发性喉乳头状瘤，此前未接受过放疗，但因阻塞性喉乳头状瘤接受了气管切开术。静脉注射阿糖胞苷、“中等剂量”甲氨蝶呤、局部使用5-氟尿嘧啶和放疗均未能改变肿瘤生长，患者最终死于复发性动脉肿瘤栓塞。