Laboratory of Anatomy-Histology-Embryology, School of Medicine, University of Crete, Heraklion, Greece.
Immunology Department, "Victor Babes" National Institute of Pathology, Bucharest, Romania.
Front Immunol. 2019 Apr 24;10:875. doi: 10.3389/fimmu.2019.00875. eCollection 2019.
Disparity during the resolution of inflammation is closely related with the initiation and progression of the tumorigenesis. The transformed cells, through continuously evolving interactions, participate in various exchanges with the surrounding microenvironment consisting of extracellular matrix (ECM) components, cytokines embedded in the ECM, as well as the stromal cells. Proteoglycans (PGs), complex molecules consisting of a protein core into which one or more glycosaminoglycan (GAG) chains are covalently tethered, are important regulators of the cell/matrix interface and, consecutively, biological functions. The discrete expression of PGs and their interacting partners has been distinguished as specific for disease development in diverse cancer types. In this mini-review, we will critically discuss the roles of PGs in the complex processes of cancer-associated modulation of the immune response and analyze their mechanisms of action. A deeper understanding of mechanisms which are capable of regulating the immune response could be harnessed to treat malignant disease.
炎症消退过程中的差异与肿瘤发生的启动和进展密切相关。转化细胞通过不断进化的相互作用，与细胞外基质 (ECM) 成分、嵌入 ECM 的细胞因子以及基质细胞组成的周围微环境进行各种交流。蛋白聚糖 (PGs) 是由一个或多个糖胺聚糖 (GAG) 链共价连接到蛋白质核心上的复杂分子，是细胞/基质界面的重要调节剂，也是生物功能的重要调节剂。PGs 及其相互作用伙伴的离散表达已被确定为多种癌症类型中疾病发展的特异性标志。在这篇迷你综述中，我们将批判性地讨论 PGs 在癌症相关免疫反应调节的复杂过程中的作用，并分析它们的作用机制。更深入地了解能够调节免疫反应的机制，可以用于治疗恶性疾病。
