Agha-Mohammadhasani Parvin, Mokhtaree Mohammadreza, Nazari Alireza, Rahnama Amir
Assistant Professor, Department of Psychiatry, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Addict Health. 2018 Apr;10(2):76-85. doi: 10.22122/ahj.v10i2.540.
Substance abuse and consequently the use of methadone in Iran are reported at high levels. Drugs alter sexual function by affecting the organs of the body. The aim of this study was to evaluate sexual functioning and serum testosterone levels in opiate addicts, individuals receiving methadone maintenance treatment (MMT), and healthy men living in the city of Rafsanjan, Iran, in 2016.
The statistical population of this descriptive study included: A) opium-smoking men, B) individuals undergoing MMT, and C) those without any history of substance abuse. Using a formula, the sample size consisted of 70 individuals who were randomly selected from the statistical population. The study samples also completed the International Index of Erectile Function (IIEF). Moreover, the serum testosterone levels were measured using the laboratory-based Enzyme Linked Immunosorbent Assay (ELISA) diagnostic kits. The data were analyzed by SPSS software using Mann-Whitney U and Kruskal-Wallis tests with a significant level of < 0.050.
The serum testosterone levels in healthy individuals were higher than those in other two groups (P = 0.001). In addition, the sexual functioning indicators of men receiving MMT and opiate-smoking ones (P = 0.001) were lower than those of healthy individuals except for overall sexual satisfaction (P = 0.069).
Methadone and opium reduce different aspects of sexual functioning. It seems that this change was through having impacts on serum testosterone levels; however, psychological, social, and economic dimensions are suggested to be considered in this domain.
据报道，伊朗的药物滥用以及随之而来的美沙酮使用情况处于较高水平。药物通过影响身体器官来改变性功能。本研究的目的是评估2016年伊朗拉夫桑詹市阿片类成瘾者、接受美沙酮维持治疗（MMT）的个体以及健康男性的性功能和血清睾酮水平。
这项描述性研究的统计人群包括：A）吸食鸦片的男性，B）接受MMT的个体，以及C）无任何药物滥用史的个体。使用公式计算，样本量由从统计人群中随机选取的70名个体组成。研究样本还完成了国际勃起功能指数（IIEF）。此外，使用基于实验室的酶联免疫吸附测定（ELISA）诊断试剂盒测量血清睾酮水平。数据通过SPSS软件使用Mann-Whitney U检验和Kruskal-Wallis检验进行分析，显著性水平<0.050。
健康个体的血清睾酮水平高于其他两组（P = 0.001）。此外，接受MMT的男性和吸食鸦片的男性的性功能指标（P = 0.001）低于健康个体，但总体性满意度除外（P = 0.069）。
美沙酮和鸦片会降低性功能的不同方面。这种变化似乎是通过对血清睾酮水平产生影响；然而，在这一领域建议考虑心理、社会和经济层面。
