通过激活癌胚抗原相关细胞黏附分子1（CEACAM1）抑制抗肿瘤免疫。
supresses anti-tumor immunity by activating CEACAM1.
作者信息
Gur Chamutal, Maalouf Naseem, Shhadeh Amjad, Berhani Orit, Singer Bernhard B, Bachrach Gilad, Mandelboim Ofer
机构信息
The Lautenberg Center of General and Tumor Immunology, The Hebrew University Hadassah Medical School, Institute for Medical Research Israel-Canada (IMRIC), Jerusalem, Israel.
The Institute of Dental Sciences, The Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel.
出版信息
Oncoimmunology. 2019 Mar 27;8(6):e1581531. doi: 10.1080/2162402X.2019.1581531. eCollection 2019.
Abstract
) is an oral anaerobe found to be enriched in colorectal cancer (CRC). Presence of in CRC has been correlated with resistance to chemotherapy and poor prognosis. We previously demonstrated that the Fap2 outer-surface protein of binds and activates the human inhibitory receptor TIGIT which is expressed by T and Natural Killer (NK) cells, and inhibits anti-tumor immunity. Here we show that also binds and activates the human inhibitory receptor CEACAM1 leading to inhibition of T and NK cells activities. Our results suggest that using CEACAM1 and TIGIT inhibitors and specific targeting of fusobacteria should be considered for treating fusobacteria-colonized tumors.
摘要
（某菌）是一种在结直肠癌（CRC）中富集的口腔厌氧菌。CRC中该菌的存在与化疗耐药性和不良预后相关。我们之前证明，该菌的Fap2外表面蛋白与人类抑制性受体TIGIT结合并激活TIGIT，TIGIT由T细胞和自然杀伤（NK）细胞表达，从而抑制抗肿瘤免疫。在此我们表明，该菌还与人类抑制性受体CEACAM1结合并激活CEACAM1，导致T细胞和NK细胞活性受到抑制。我们的结果表明，在治疗被梭杆菌定植的肿瘤时，应考虑使用CEACAM1和TIGIT抑制剂以及对梭杆菌进行特异性靶向治疗。
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