Scriba Gerhard K E
Department of Pharmaceutical Chemistry, University of Jena, Jena, Germany.
Methods Mol Biol. 2019;1985:1-33. doi: 10.1007/978-1-4939-9438-0_1.
Stereospecific recognition of chiral molecules plays an important role in nature as the basis of the interaction of chiral bioactive compounds with the chiral target structures. In separation sciences such as chromatographic and capillary electromigration techniques, interactions between chiral analytes and chiral selectors, i.e., the formation of transient diastereomeric complexes in thermodynamic equilibria, are the basis for chiral separations. Due to the large structural variety of chiral selectors, different structural features contribute to the overall chiral recognition process. This introductory chapter briefly summarizes the present understanding of the structural enantioselective recognition processes for various types of chiral selectors.
手性分子的立体选择性识别在自然界中起着重要作用，它是手性生物活性化合物与手性靶标结构相互作用的基础。在色谱和毛细管电迁移技术等分离科学中，手性分析物与手性选择剂之间的相互作用，即在热力学平衡中形成瞬态非对映体复合物，是手性分离的基础。由于手性选择剂的结构种类繁多，不同的结构特征对手性识别的整体过程都有贡献。本章引言简要总结了目前对各类手性选择剂结构对映选择性识别过程的理解。
