Wang Lijuan, Hou Xu, Zhang Fan, Liu Ying, Ren Yimeng, Yan Hongyuan
Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding, China.
Key Laboratory of Medical Chemistry and Molecular Diagnosis, Ministry of Education, Hebei University, Baoding, China.
Methods Mol Biol. 2019;1985:383-389. doi: 10.1007/978-1-4939-9438-0_22.
Nonaqueous capillary electrophoresis (NACE) is an effective method for chiral separation. Many polyol derivatives (e.g., D-(+)-xylose, lactobionic acid, diacetone-D-mannitol, L-sorbose, and D-gluconic acid δ-lactone) can react with boric acid in methanol to produce polyol derivative-boric acid complexes which can be utilized as chiral selectors of enantioseparations. The enantiomers of more than a dozen basic analytes can be resolved under the optimized NACE using these chiral selectors.
非水毛细管电泳（NACE）是一种有效的手性分离方法。许多多元醇衍生物（如D-(+)-木糖、乳糖酸、双丙酮-D-甘露醇、L-山梨糖和D-葡萄糖酸δ-内酯）可与甲醇中的硼酸反应生成多元醇衍生物-硼酸络合物，这些络合物可作为对映体分离的手性选择剂。使用这些手性选择剂，在优化的NACE条件下可拆分十几种碱性分析物的对映体。
