围产期营养不良的成年大鼠经反复地昔帕明（DMI）治疗后抗不动效应减弱。
Reduced anti-immobility effect of repeated desipramine (DMI) treatment in adult rats undernourished at perinatal age.
作者信息
Molina V A, Keller E A, Orsingher O A
出版信息
Pharmacol Biochem Behav. 1987 Feb;26(2):417-9. doi: 10.1016/0091-3057(87)90139-0.
PMID:3106992
Abstract
Adult rats submitted to a protein deprivation schedule at perinatal age showed a reduced anti-immobility effect following seven days of DMI treatment (20 mg/kg/day) in the forced swimming test. The ineffectiveness of DMI treatment is attributed to the inability of deprived animals to produce neuronal adaptative changes in central monoaminergic pathways.
摘要
在围产期经历蛋白质剥夺计划的成年大鼠，在强迫游泳试验中接受七天的二甲基色胺（DMI）治疗（20毫克/千克/天）后，抗不动效应降低。DMI治疗无效归因于缺乏蛋白质的动物无法在中枢单胺能通路中产生神经元适应性变化。
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