Ohno M, Yamamoto T, Araki H, Ueki S
Psychopharmacology (Berl). 1987;91(2):189-92. doi: 10.1007/BF00217060.
The effect of a selective kappa-opioid agonist, U-50, 488H, on wet-dog shaking (WDS) induced by hippocampal stimulation was investigated and compared with that produced by morphine. U-50, 488H, as well as morphine, inhibited the appearance of WDS in a dose-dependent manner. U-50, 488H was approximately three times more potent than morphine in this effect. Neither drug showed any effect on hippocampal afterdischarge. The inhibition of WDS produced by U-50, 488H was blocked significantly by a kappa-opioid antagonist, MR-2266, but not by naloxone. On the other hand, the inhibitory effect of morphine was completely antagonized by both MR-2266 and naloxone. The present results strongly suggest that not only mu-but also kappa-opioid receptors are involved in the appearance of WDS induced by hippocampal stimulation.
研究了选择性κ-阿片受体激动剂U-50,488H对海马刺激诱导的湿狗摇晃（WDS）的影响，并与吗啡产生的影响进行了比较。U-50,488H以及吗啡均以剂量依赖性方式抑制WDS的出现。在这种作用中，U-50,488H的效力约为吗啡的三倍。两种药物对海马后放电均无任何影响。U-50,488H产生的对WDS的抑制作用被κ-阿片受体拮抗剂MR-2266显著阻断，但不被纳洛酮阻断。另一方面，吗啡的抑制作用被MR-2266和纳洛酮完全拮抗。目前的结果强烈表明，不仅μ-阿片受体，而且κ-阿片受体也参与了海马刺激诱导的WDS的出现。
