Manipal Centre for Virus Research, Manipal Academy of Higher Education (MAHE), Manipal, India.
Viral Immunol. 2019 Jun;32(5):230-233. doi: 10.1089/vim.2019.0010. Epub 2019 May 9.
Influenza viruses are major respiratory pathogens that cause seasonal epidemics and occasional pandemics. Immune response to influenza viruses is majorly targeted against the hemagglutinin antigen. A laboratory-based retrospective cross-sectional study was conducted on 50 acute and 50 follow-up samples to assess the immune response to influenza A(H1N1)pdm09 virus after natural infection and detect the presence of pre-existing antibodies against influenza A(H3N2) and influenza B viruses. Two-fourfold rise in hemagglutination-inhibition (HAI) titer was observed in 100% of the follow-up samples for influenza A(H1N1)pdm09 virus. No change in HAI titers for influenza A(H3N2) and influenza B viruses was observed.
流感病毒是主要的呼吸道病原体，可引起季节性流行和偶发性大流行。针对流感病毒的免疫反应主要针对血凝素抗原。对 50 份急性和 50 份随访样本进行了基于实验室的回顾性横断面研究，以评估自然感染后对甲型 H1N1pdm09 流感病毒的免疫反应，并检测针对甲型 H3N2 和乙型流感病毒的预先存在的抗体。在随访样本中，甲型 H1N1pdm09 病毒的血凝抑制（HAI）滴度均观察到了 2-4 倍的升高。而甲型 H3N2 和乙型流感病毒的 HAI 滴度没有变化。
