Bodewes R, de Mutsert G, van der Klis F R M, Ventresca M, Wilks S, Smith D J, Koopmans M, Fouchier R A M, Osterhaus A D M E, Rimmelzwaan G F
Department of Virology, Erasmus Medical Center, P.O. Box 2040, 3000 CA Rotterdam, Netherlands.
Clin Vaccine Immunol. 2011 Mar;18(3):469-76. doi: 10.1128/CVI.00396-10. Epub 2011 Jan 5.
To gain insight into the age at which children become infected with influenza viruses for the first time, we analyzed the seroprevalence of antibodies against influenza viruses in children 0 to 7 years of age in the Netherlands. Serum samples were collected during a cross-sectional population-based study in 2006 and 2007 and were tested for the presence of antibodies against influenza A/H1N1, A/H3N2, and B viruses representative of viruses present in previous influenza seasons using the hemagglutination inhibition assay. The seroprevalence of antibodies to influenza virus was higher in children 1 to 6 months of age than in children 7 to 12 months of age, which likely reflects the presence of maternally derived antibodies. The proportion of study subjects >1 year of age with detectable antibodies against influenza viruses gradually increased with age until they reached the age of 6 years, when they all had antibodies to at least one influenza A virus. These findings may have implications for the development of vaccination strategies aiming at the protection of young children against seasonal and/or pandemic influenza virus infection.
为深入了解儿童首次感染流感病毒的年龄，我们分析了荷兰0至7岁儿童中抗流感病毒抗体的血清流行率。血清样本是在2006年和2007年一项基于人群的横断面研究中收集的，并使用血凝抑制试验检测了针对代表前几个流感季节存在的病毒的甲型H1N1、甲型H3N2和乙型流感病毒的抗体。1至6个月龄儿童中流感病毒抗体的血清流行率高于7至12个月龄儿童，这可能反映了母源抗体的存在。1岁以上可检测到抗流感病毒抗体的研究对象比例随年龄逐渐增加，直至6岁时，他们都至少对一种甲型流感病毒有抗体。这些发现可能对旨在保护幼儿免受季节性和/或大流行性流感病毒感染的疫苗接种策略的制定具有启示意义。
