人类粒细胞特异性核抗原。I：抗血清的制备及特异性测定。
Human granulocyte specific nuclear antigen(s). I: Production of antisera and determination of specificity.
作者信息
Briggs R C, Chiu J F, Hnilica L S, Chytil F, Rogers L W, Page D L
出版信息
Cell Differ. 1978 Dec;7(6):313-23. doi: 10.1016/0045-6039(78)90032-5.
PMID:310712
Abstract
Non-histone protein-DNA complexes isolated from human lung tissue were used to immunize New Zealand rabbits. Quantitative microcomplement fixation and immunocytochemistry revealed a specific chromatin antigen(s) in the human granulocyte nucleus. The study demonstrates the feasibility of employing antisera against chromosomal non-histone protein-DNA complexes for the immunochemical identification of cell types.
摘要
从人肺组织中分离出的非组蛋白- DNA复合物被用于免疫新西兰兔。定量微量补体结合试验和免疫细胞化学显示人粒细胞核内存在一种特异性染色质抗原。该研究证明了利用抗染色体非组蛋白- DNA复合物的抗血清对细胞类型进行免疫化学鉴定的可行性。
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