Topaktaş Ramazan, Ürkmez Ahmet, Kutluhan Musab Ali, Çalışkan Selahattin, Erel Özcan
Department of Urology, Haydarpasa Numune Research and Training Hospital, Istanbul, Turkey.
Department of Urology, Fatih Sultan Mehmet Research and Training Hospital, Istanbul, Turkey.
Aging Male. 2020 Dec;23(5):860-864. doi: 10.1080/13685538.2019.1608519. Epub 2019 May 10.
We aimed to evaluate plasma thiol and disulphide levels as an additional marker to prostate specific antigen (PSA) in the diagnosis of prostate cancer (PCa).
Between March 2017 and January 2018 prospective study was conducted among patients with PSA levels of 2.5-20 ng/mL without suspicion of malignancy in rectal examination and who underwent prostate needle biopsy. Patients were divided into two groups according to PSA level as 2.5-10 ng/mL (Group 1) and 10.01-20 ng/mL (Group 2). Diagnostic efficacy of thiol, disulphide and PSA levels were measured by ROC analysis.
A total of 76 patients were included in the study. There were 49 patients in group 1 and 27 patients in group 2. There was no significant difference between two groups in terms of PSA density and prostate size. In Group 1, area under curve (AUC) was higher in PSA than other parameters with statistically significant difference (<.05). In group 2, AUC of native and total thiol was higher than PSA but there was no statistically significant difference for AUC in parameters.
We think that plasma thiol test may be used in diagnosis of prostate cancer while PSA levels between 10 to 20 ng/mL. However, further studies are required.
我们旨在评估血浆硫醇和二硫化物水平，作为前列腺特异性抗原（PSA）之外的另一种标志物，用于前列腺癌（PCa）的诊断。
在2017年3月至2018年1月期间，对直肠指检未怀疑恶性肿瘤且PSA水平为2.5 - 20 ng/mL并接受前列腺穿刺活检的患者进行了前瞻性研究。根据PSA水平将患者分为两组，即2.5 - 10 ng/mL（第1组）和10.01 - 20 ng/mL（第2组）。通过ROC分析测量硫醇、二硫化物和PSA水平的诊断效能。
共有76例患者纳入研究。第1组有49例患者，第2组有27例患者。两组在PSA密度和前列腺大小方面无显著差异。在第1组中，PSA的曲线下面积（AUC）高于其他参数，差异有统计学意义（<.05）。在第2组中，天然硫醇和总硫醇的AUC高于PSA，但各参数的AUC之间无统计学差异。
我们认为，当PSA水平在10至20 ng/mL之间时，血浆硫醇检测可用于前列腺癌的诊断。然而，还需要进一步研究。
