1 Department of Neurosurgery, Shenzhen People's Hospital, The Second Clinical Medical College of Jinan University, Shenzhen, China.
Technol Cancer Res Treat. 2019 Jan 1;18:1533033819846636. doi: 10.1177/1533033819846636.
Angiogenin is a small protein that exerts potent stimulating effects on angiogenesis. In this study, we aimed to examine the expression of angiogenin in different subtypes of glioblastoma and estimated its independent prognostic value.
The genomic and survival data from The Cancer Genome Atlas-glioblastoma were extracted for a secondary study. Results The expression of angiogenin was upregulated in glioblastoma tissues and varied significantly in different subtypes. Although the proneural subtype had the lowest angiogenin expression, high angiogenin expression was associated with significantly worse overall survival. However, this association was not observed in other subtypes. By performing univariate and multivariate analysis using Cox regression model, we observed that high angiogenin expression was an independent indicator of shorter overall survival in proneural glioblastoma (hazard ratio: 1.669, 95% confidence interval: 1.033-2.696, P = .036), after adjustment of age, gender, isocitrate dehydrogenase 1 mutation, temozolomide chemotherapy and radiation therapy. In addition, we also observed a correlation between elevated angiogenin expression and the hypomethylated status of its DNA. The hypermethylation group had significantly better overall survival.
Angiogenin upregulation might serve as a biomarker for unfavorable overall survival in the proneural subtype of glioblastoma.
血管生成素是一种具有强烈促血管生成作用的小蛋白。本研究旨在检测血管生成素在不同胶质母细胞瘤亚型中的表达，并评估其独立的预后价值。
从癌症基因组图谱-胶质母细胞瘤中提取基因组和生存数据进行二次研究。结果血管生成素在胶质母细胞瘤组织中呈上调表达，且在不同亚型中差异显著。尽管原神经型表达最低，但高血管生成素表达与总生存期显著缩短相关。然而，在其他亚型中并未观察到这种相关性。通过使用 Cox 回归模型进行单因素和多因素分析，我们观察到在原神经型胶质母细胞瘤中，高血管生成素表达是总生存期较短的独立指标（风险比：1.669，95%置信区间：1.033-2.696，P=0.036），在调整年龄、性别、异柠檬酸脱氢酶 1 突变、替莫唑胺化疗和放疗后。此外，我们还观察到血管生成素表达升高与 DNA 去甲基化状态之间存在相关性。高甲基化组的总生存期明显更好。
血管生成素的上调可能成为原神经型胶质母细胞瘤总生存期不良的生物标志物。
