Mao Mingwen, Chen Weina, Ye Dong
Department of Otorhinolaryngology-Head and Neck Surgery, Ningbo No.6 Hospital Affiliated Medical School of Ningbo University, 315040, Ningbo, Zhejiang, China.
Department of Otorhinolaryngology-Head and Neck Surgery, Lihuili Hospital of Ningbo University, 315040, Ningbo, Zhejiang, China.
Heliyon. 2024 May 3;10(9):e30654. doi: 10.1016/j.heliyon.2024.e30654. eCollection 2024 May 15.
Angiogenin (ANG) is a specialised secreted ribonuclease, also known as RNase5, that is widely expressed in vertebrates. ANG dysregulation is closely associated with the development of breast, nasopharyngeal, and lung cancers. In recent years, studies have found that ANG not only induces neovascularisation by activating endothelial cells, but also plays a regulatory role in the plasticity of cancer cells. Cellular plasticity plays pivotal roles in cancer initiation, progression, migration, therapeutic resistance, and relapse. Therefore, it is a promising biomarker for cancer diagnosis, prognostic evaluation, and therapy. This review summarises the current knowledge regarding the roles and clinical applications of ANG in cancer development and progression.
血管生成素（ANG）是一种特殊的分泌型核糖核酸酶，也被称为核糖核酸酶5（RNase5），在脊椎动物中广泛表达。ANG失调与乳腺癌、鼻咽癌和肺癌的发生密切相关。近年来，研究发现ANG不仅通过激活内皮细胞诱导新血管形成，还在癌细胞的可塑性中发挥调节作用。细胞可塑性在癌症的起始、进展、迁移、治疗抗性和复发中起关键作用。因此，它是一种有前景的癌症诊断、预后评估和治疗的生物标志物。本综述总结了目前关于ANG在癌症发生和进展中的作用及临床应用的知识。
