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Cryptic insertion of exons 2 and 3 into the immunoglobulin heavy chain locus detected by whole genome sequencing in a case of "-negative" Burkitt lymphoma.

作者信息

Wagener Rabea, Bens Susanne, Toprak Umut H, Seufert Julian, López Cristina, Scholz Ingrid, Herbrueggen Heidi, Oschlies Ilske, Stilgenbauer Stephan, Schlesner Matthias, Klapper Wolfram, Burkhardt Birgit, Siebert Reiner

机构信息

Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm.

German Cancer Research Center (DKFZ), Bioinformatics and Omics Data Analytics, Heidelberg.

出版信息

Haematologica. 2020 Apr;105(4):e202-e205. doi: 10.3324/haematol.2018.208140. Epub 2019 May 9.

DOI:10.3324/haematol.2018.208140
PMID:31073073
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7109723/
Abstract
摘要

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Cryptic insertion of exons 2 and 3 into the immunoglobulin heavy chain locus detected by whole genome sequencing in a case of "-negative" Burkitt lymphoma.在一例“-阴性”伯基特淋巴瘤中，通过全基因组测序检测到外显子2和3隐匿插入到免疫球蛋白重链基因座。
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2
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Nat Commun. 2019 Mar 29;10(1):1459. doi: 10.1038/s41467-019-08578-3.
2
Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma.弥漫性大B细胞淋巴瘤的遗传和功能驱动因素
Cell. 2017 Oct 5;171(2):481-494.e15. doi: 10.1016/j.cell.2017.09.027.
3
Relevance of ID3-TCF3-CCND3 pathway mutations in pediatric aggressive B-cell lymphoma treated according to the non-Hodgkin Lymphoma Berlin-Frankfurt-Münster protocols.根据非霍奇金淋巴瘤柏林-法兰克福-明斯特方案治疗的儿童侵袭性B细胞淋巴瘤中ID3-TCF3-CCND3通路突变的相关性
Haematologica. 2017 Jun;102(6):1091-1098. doi: 10.3324/haematol.2016.156885. Epub 2017 Feb 16.
4
Clinical and pathological features of Burkitt lymphoma showing expression of BCL2--an analysis including gene expression in formalin-fixed paraffin-embedded tissue.显示BCL2表达的伯基特淋巴瘤的临床和病理特征——一项包括福尔马林固定石蜡包埋组织中基因表达的分析
Br J Haematol. 2015 Nov;171(4):501-8. doi: 10.1111/bjh.13624. Epub 2015 Jul 27.
5
A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma.一种反复出现的 11q 异常模式，其特征在于类似于伯基特淋巴瘤的一部分 MYC 阴性高级别 B 细胞淋巴瘤。
Blood. 2014 Feb 20;123(8):1187-98. doi: 10.1182/blood-2013-06-507996. Epub 2014 Jan 7.
6
The genetic landscape of mutations in Burkitt lymphoma.伯基特淋巴瘤突变的遗传特征。
Nat Genet. 2012 Dec;44(12):1321-5. doi: 10.1038/ng.2468. Epub 2012 Nov 11.
7
Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing.通过整合基因组、外显子组和转录组测序鉴定伯基特淋巴瘤中 ID3 基因的反复突变。
Nat Genet. 2012 Dec;44(12):1316-20. doi: 10.1038/ng.2469. Epub 2012 Nov 11.
8
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics.从结构和功能基因组学角度探讨伯基特淋巴瘤的发病机制和治疗靶点。
Nature. 2012 Oct 4;490(7418):116-20. doi: 10.1038/nature11378. Epub 2012 Aug 12.
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Double-hit B-cell lymphomas.双打击 B 细胞淋巴瘤。
Blood. 2011 Feb 24;117(8):2319-31. doi: 10.1182/blood-2010-09-297879. Epub 2010 Nov 30.
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Detection of genomic aberrations in molecularly defined Burkitt's lymphoma by array-based, high resolution, single nucleotide polymorphism analysis.通过基于阵列的、高分辨率的单核苷酸多态性分析检测分子定义的伯基特淋巴瘤中的基因组异常。
Haematologica. 2010 Dec;95(12):2047-55. doi: 10.3324/haematol.2010.026831. Epub 2010 Sep 7.