Hamlyn P H, Rabbitts T H
Nature. 1983;304(5922):135-9. doi: 10.1038/304135a0.
Recombinant DNA clones have been used to directly demonstrate that the Burkitt lymphoma cell line Raji, t(8;14) (q24;q32), has a rearranged copy of the c-myc gene adjacent to the gamma 1 constant region gene of the human immunoglobulin heavy-chain locus; the genes are arranged in the opposite direction for transcription. At least one further 5' exon has been detected in the normal c-myc gene by analysis of RNA transcripts, and the occurrence of high levels of two c-myc mRNA size classes, both apparently initiating in this exon, is described.
重组DNA克隆已被用于直接证明，伯基特淋巴瘤细胞系Raji，t(8;14)(q24;q32)，在人类免疫球蛋白重链基因座的γ1恒定区基因附近有一个重排的c-myc基因拷贝；这些基因在转录方向上相反。通过对RNA转录本的分析，在正常c-myc基因中至少检测到另外一个5'外显子，并描述了两种c-myc mRNA大小类别的高水平出现情况，这两种大小类别显然都起始于该外显子。
