Tekes K, Tothfalusi T, Magyar K
Acta Physiol Pharmacol Bulg. 1986;12(4):21-8.
Rats were exposed to irregular chronic stress (IRCS, an animal model of depression). Changes in dopamine and serotonin utilization by striata and hippocampi were measured. IRCS did not influence serotonin uptake, serotonin, dopamine, 5-hydroxyindolacetic acid and homovanillic acid levels, while it decreased 3,4-dihydroxyphenylacetic acid level and dopamine uptake. This would reflect selective presynaptic adaptation to IRCS. Neither (-)deprenyl (21 X 0.25 mg/kg, s.c.), nor amitriptyline (21 X X 15 mg/kg, i.p.) could prevent the effects of IRCS.
将大鼠暴露于不规则慢性应激（IRCS，一种抑郁症动物模型）。测量纹状体和海马体中多巴胺和5-羟色胺利用情况的变化。IRCS不影响5-羟色胺摄取、5-羟色胺、多巴胺、5-羟吲哚乙酸和高香草酸水平，但会降低3,4-二羟基苯乙酸水平和多巴胺摄取。这反映了对IRCS的选择性突触前适应。（-）司来吉兰（21×0.25毫克/千克，皮下注射）和阿米替林（21×15毫克/千克，腹腔注射）均不能预防IRCS的影响。
