Patki Vinayak K, Antin Jennifer V, Khare Shweta H
Department of Pediatrics, Institute of Medical Education and Research, Vidyagiri, Satara, Maharashtra, India.
Department of Pediatrics, Wanless Hospital, Miraj, Sangli, Maharashtra, India.
J Pediatr Intensive Care. 2017 Sep;6(3):152-158. doi: 10.1055/s-0036-1593886. Epub 2016 Nov 10.
To study incidence of hyperlactatemia and its correlation with outcome in critically ill children. Single-center, prospective cohort study. Eight-bedded PICU. Serial serum lactate levels were measured in 140 critically ill children at 0, 12, 24, and 48 hours. A total of 45% children had hyperlactatemia. Lactate levels were significantly ( = 0.000) higher in nonsurvivors at all intervals. Lactate levels decreased significantly ( = 0.000) in survivors while increased in nonsurvivors. Normalized lactate load was found to be an independent predictor of mortality ( = 0.023). Persistent hyperlactatemia serves as a possible predictor of poor outcome in critically ill children.
研究危重症儿童高乳酸血症的发生率及其与预后的相关性。 单中心前瞻性队列研究。 设有8张床位的儿科重症监护病房（PICU）。 对140例危重症儿童在0、12、24和48小时测量其血清乳酸水平。 共有45%的儿童患有高乳酸血症。在所有时间点，非存活者的乳酸水平均显著更高（P = 0.000）。存活者的乳酸水平显著下降（P = 0.000），而非存活者的乳酸水平则升高。标准化乳酸负荷被发现是死亡率的独立预测因素（P = 0.023）。 持续性高乳酸血症可能是危重症儿童预后不良的预测指标。
