Key Laboratory of Materials Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China.
Department of Rehabilitation Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China.
Mikrochim Acta. 2019 May 9;186(6):337. doi: 10.1007/s00604-019-3406-9.
A nanocomposite (NC) of type Cu/CuO/CuO@MoS was obtained via coprecipitation and a hydrothermal approach from copper oxide nanoparticles and MoS nanostructures. A series of nanocomposites has been fabricated with varying fractions of MoS. The NCs were characterized by XRD, XPS, SEM and TEM. The synergistic effect of enlarged specific surface, high electrocatalytic activity and the presence of mixed valencies strongly enhance the redox response at the interface of a glassy carbon electrode (GCE) modified with the NC. The intercalation properties of MoS in the NCs result in outstanding electro-oxidative performance towards bisphenol A (BPA). The modified GCE, best operated at +0.16 V vs. SCE, has a linear response in the 0.0001 μM to 17 μM BPA concentration range (R = 0.998) and high sensitivity (1587 mA μM cm). The sensor can detect BPA with very good selectivity, enhanced storage stability and a low detection limit of 0.10 nM (S/N = 3). This is the lowest value among the non-enzymatic biosensors reported until now. The sensor was used for real-time in-vitro monitoring of BPA in (spiked) serum samples. Graphical abstract Schematic representation of Cu/CuO/CuO@MoS hybrid material fabricated by a hydrothermal method for sensitive determination of bisphenol A (BPA) from biological fluids.
一种类型为 Cu/CuO/CuO@MoS 的纳米复合材料（NC）是通过共沉淀和水热法从氧化铜纳米粒子和 MoS 纳米结构中获得的。制备了一系列具有不同 MoS 分数的纳米复合材料。NCs 通过 XRD、XPS、SEM 和 TEM 进行了表征。增大的比表面积、高电催化活性和混合价态的存在的协同效应强烈增强了玻璃碳电极（GCE）修饰层上的氧化还原响应。NC 中 MoS 的嵌入特性导致其对双酚 A（BPA）具有出色的电氧化性能。修饰后的 GCE 在+0.16 V 相对于 SCE 下最佳工作，在 0.0001 μM 至 17 μM BPA 浓度范围内具有线性响应（R = 0.998）和高灵敏度（1587 mA μM cm）。该传感器对 BPA 具有非常好的选择性、增强的存储稳定性和低检测限 0.10 nM（S/N = 3）。这是迄今为止报道的非酶生物传感器中的最低值。该传感器用于实时监测（加标）血清样品中的 BPA。
