Asif Muhammad, Xu Yun, Xiao Fei, Sun Yimin
Hubei Key Laboratory of Plasma Chemistry and Advanced Materials, School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430205, China.
Hubei Key Laboratory of Material Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430205, China.
Chem Eng J. 2021 Nov 1;423:130189. doi: 10.1016/j.cej.2021.130189. Epub 2021 May 7.
Coronavirus diseases-2019 (COVID-19) is becoming increasing serious and major threat to public health concerns. As a matter of fact, timely testing enhances the life-saving judgments on treatment and isolation of COVID-19 infected individuals at possible earliest stage which ultimately suppresses spread of infectious diseases. Many government and private research institutes and manufacturing companies are striving to develop reliable tests for prompt quantification of SARS-CoV-2. In this review, we summarize existing diagnostic methods as manual laboratory-based nucleic acid assays for COVID-19 and their limitations. Moreover, vitality of rapid and point of care serological tests together with emerging biosensing technologies has been discussed in details. Point of care tests with characteristics of rapidity, accurateness, portability, low cost and requiring non-specific devices possess great suitability in COVID-19 diagnosis and detection. Besides, this review also sheds light on several preventive measures to track and manage disease spread in current and future outbreaks of diseases.
2019冠状病毒病（COVID-19）正变得日益严重，对公众健康构成重大威胁。事实上，及时检测能够在尽可能早的阶段增强对COVID-19感染者进行治疗和隔离的救命判断，最终抑制传染病的传播。许多政府和私人研究机构以及制造公司都在努力开发可靠的检测方法，以便迅速对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）进行定量检测。在这篇综述中，我们总结了现有的诊断方法，即基于实验室的COVID-19手动核酸检测方法及其局限性。此外，还详细讨论了快速即时检测血清学检测以及新兴生物传感技术的重要性。具有快速、准确、便携、低成本且无需特殊设备特点的即时检测在COVID-19诊断和检测中具有很大的适用性。此外，本综述还阐明了在当前和未来疾病爆发中追踪和管理疾病传播的几种预防措施。
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