Bundeswehr Institute of Microbiology, 80937, Munich, Germany.
National Consultant Laboratory for Brucellosis, 80937, Munich, Germany.
Infection. 2019 Oct;47(5):863-868. doi: 10.1007/s15010-019-01312-7. Epub 2019 May 9.
In July 2018, brucellosis was diagnosed in a German patient without a travel history to regions endemic for Brucella. Microbiological analysis, including whole-genome sequencing, revealed Brucella suis biovar 1 as the etiologic agent. Core-genome-based multilocus sequence-typing analysis placed the isolate in close proximity to strains originating from Argentina. Notably, despite a strong IgM response, the patient did not develop Brucella-specific IgG antibodies during infection. Here, we describe the clinical course of infection, the extensive epidemiological investigations, and discuss possible routes of transmission.
2018 年 7 月，一名无布鲁氏菌病流行地区旅行史的德国患者被诊断患有布鲁氏菌病。微生物学分析，包括全基因组测序，显示布鲁氏菌 1 亚种为病原体。基于核心基因组的多位点序列分型分析将该分离株与源自阿根廷的菌株紧密相连。值得注意的是，尽管患者的 IgM 反应强烈，但在感染过程中并未产生布鲁氏菌特异性 IgG 抗体。在这里，我们描述了感染的临床过程、广泛的流行病学调查，并讨论了可能的传播途径。
