Department of Immunology, Medical College, Henan University of Science and Technology, Luoyang, China.
Network Information Center, Children's Hospital of Kaifeng City, Kaifeng, China.
J Cell Biochem. 2019 Sep;120(9):15867-15873. doi: 10.1002/jcb.28857. Epub 2019 May 9.
The findings regarding the relation of transporter associated with antigen processing (TAP) to cancer risk have been inconsistent. The aim of this study was to comprehensively evaluate the association between TAP2 rs241447 polymorphism and cancer susceptibility. A meta-analysis of nine investigations with 2800 cases and 1620 controls was conducted to gain a better understanding of the effect of TAP2 rs241447 polymorphism on cancer risk. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of the correlation between TAP2 gene polymorphism and cancer susceptibility. The pooled results from TAP2 rs241447 polymorphism showed a decreased risk of cancer in two dominant genetic models (GG + AG vs AA: OR = 0.86, 95% CI, 0.75-0.99; AG vs AA: OR = 0.85, 95% CI, 0.73-0.99). From the subgroup analysis, decreased cancer susceptibility was found in Caucasians (GG + AG vs AA: OR = 0.82, 95% CI, 0.68-0.99), especially among the subgroup of cervical carcinoma (GG + AG vs AA: OR = 0.82, 95% CI, 0.69-0.96; AG vs AA: OR = 0.83, 95% CI, 0.70-0.99). Overall, the results suggest that TAP2 rs241447 polymorphism contributes to decreased cancer susceptibility.
关于抗原加工相关转运体（TAP）与癌症风险的关系的研究结果一直不一致。本研究旨在全面评估 TAP2 rs241447 多态性与癌症易感性之间的关系。对 9 项研究进行了荟萃分析，共纳入 2800 例病例和 1620 例对照，以更好地了解 TAP2 rs241447 多态性对癌症风险的影响。使用比值比（OR）和 95%置信区间（CI）来评估 TAP2 基因多态性与癌症易感性之间的相关性强度。TAP2 rs241447 多态性的汇总结果显示，两种显性遗传模型（GG+AG 与 AA：OR=0.86，95%CI，0.75-0.99；AG 与 AA：OR=0.85，95%CI，0.73-0.99）下癌症风险降低。从亚组分析来看，在白种人中发现癌症易感性降低（GG+AG 与 AA：OR=0.82，95%CI，0.68-0.99），尤其是在宫颈癌亚组中（GG+AG 与 AA：OR=0.82，95%CI，0.69-0.96；AG 与 AA：OR=0.83，95%CI，0.70-0.99）。总的来说，这些结果表明 TAP2 rs241447 多态性与癌症易感性降低有关。
