Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China.
Diagn Pathol. 2014 Jun 27;9:129. doi: 10.1186/1746-1596-9-129.
Rheumatoid arthritis (RA) is a severe chronic immune mediated inflammatory disease that has been shown to be associated with human leukocyte antigen (HLA) loci. The transporter associated with antigen processing 2 (TAP2) has been identified to play an important role in the HLA-associated diseases and immune response. The goal of our meta-analysis was to summarize the contribution of TAP2 polymorphisms to the risk of RA.
Meta-analyses were performed between RA and 3 TAP2 coding polymorphisms that comprised TAP2-379Ile > Val (rs1800454), TAP2-565Ala > Thr (rs2228396) and TAP2-665Thr > Ala (rs241447). The meta-analyses were involved with 9 studies (24 individual studies) among 973 cases and 965 controls.
Meta-analyses showed that TAP2-379Ile allele was significantly associated with an increased risk of RA (p = 0.0002, odds ratio (OR) = 1.44, 95% confidence interval (CI) = 1.18-1.74). This association was further shown only in the dominant model (p = 0.006, OR = 1.59, 95% CI = 1.14-2.22). Subgroup analyses by ethnicity revealed that the association of TAP2-379Ile was significant in Asians (p = 0.03, OR = 1.38, 95% CI = 1.04-1.83). In addition, another significant association of TAP2-565Thr allele with RA was observed in Europeans (p = 0.002, OR = 1.62, 95% CI = 1.20-2.20).
Our meta-analyses suggested that TAP2-379Ile allele was significantly associated with a 59% increased risk in the dominant effect model. Subgroup analyses by ethnicity showed that TAP2-379-Ile increased the risk of RA by 38% in Asians and TAP2-565Thr increased the risk of RA by 38% in Europeans.
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2097080313124700.
类风湿关节炎（RA）是一种严重的慢性免疫介导的炎症性疾病，已被证明与人类白细胞抗原（HLA）基因座有关。抗原加工相关转运体 2（TAP2）已被确定在 HLA 相关疾病和免疫反应中发挥重要作用。我们的荟萃分析旨在总结 TAP2 多态性对 RA 风险的贡献。
对 RA 与 3 个 TAP2 编码多态性（TAP2-379Ile>Val（rs1800454）、TAP2-565Ala>Thr（rs2228396）和 TAP2-665Thr>Ala（rs241447））进行荟萃分析。荟萃分析共纳入 9 项研究（24 项独立研究），共 973 例病例和 965 例对照。
荟萃分析显示，TAP2-379Ile 等位基因与 RA 风险增加显著相关（p=0.0002，比值比（OR）=1.44，95%置信区间（CI）=1.18-1.74）。这种关联仅在显性模型中进一步显示（p=0.006，OR=1.59，95% CI=1.14-2.22）。按种族亚组分析显示，TAP2-379Ile 与亚洲人群的关联具有统计学意义（p=0.03，OR=1.38，95% CI=1.04-1.83）。此外，还观察到 TAP2-565Thr 等位基因与 RA 的另一个显著关联在欧洲人群中（p=0.002，OR=1.62，95% CI=1.20-2.20）。
我们的荟萃分析表明，TAP2-379Ile 等位基因与显性效应模型中 59%的 RA 风险增加显著相关。按种族亚组分析显示，TAP2-379Ile 在亚洲人群中使 RA 风险增加 38%，TAP2-565Thr 在欧洲人群中使 RA 风险增加 38%。
